A review of JAK-STAT signalling in the pathogenesis of spondyloarthritis and the role of JAK inhibition

McInnes, I. B. et al. (2022) A review of JAK-STAT signalling in the pathogenesis of spondyloarthritis and the role of JAK inhibition. Rheumatology, 61(5), pp. 1783-1794. (doi: 10.1093/rheumatology/keab740) (PMID:34668515)

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Abstract

Spondyloarthritis (SpA) comprises a group of chronic inflammatory diseases with overlapping clinical, genetic and pathophysiological features including back pain, peripheral arthritis, psoriasis, enthesitis and dactylitis. Several cytokines are involved in the pathogenesis of SpA, variously contributing to each clinical manifestation. Many SpA-associated cytokines, including IL-23, IL-17, IL-6, type I/II interferon and tumour necrosis factor signal directly or indirectly via the Janus kinase (JAK)–signal transducer and activator of transcription pathway. JAK signalling also regulates development and maturation of cells of the innate and adaptive immune systems. Accordingly, disruption of this signalling pathway by small molecule oral JAK inhibitors can inhibit signalling implicated in SpA pathogenesis. Herein we discuss the role of JAK signalling in the pathogenesis of SpA and summarize the safety and efficacy of JAK inhibition by reference to relevant SpA clinical trials.

Item Type:Articles
Additional Information:This work was supported by AbbVie, who participated in the writing, review and approval of the article.
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:McInnes, Professor Iain
Authors: McInnes, I. B., Szekanecz, Z., McGonagle, D., Maksymowych, W. P., Pfeil, A., Lippe, R., Song, I.-H., Lertratanakul, A., Sornasse, T., Biljan, A., and Deodhar, A.
College/School:College of Medical Veterinary and Life Sciences > School of Infection & Immunity
Research Centre:College of Medical Veterinary and Life Sciences > School of Infection & Immunity > Centre for Immunobiology
Journal Name:Rheumatology
Publisher:Oxford University Press
ISSN:1462-0324
ISSN (Online):1462-0332
Published Online:20 October 2021
Copyright Holders:Copyright © 2021 The Authors
First Published:First published in Rheumatology 61(5): 1783-1794
Publisher Policy:Reproduced under a Creative Commons License

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