McInnes, I. B. et al. (2022) A review of JAK-STAT signalling in the pathogenesis of spondyloarthritis and the role of JAK inhibition. Rheumatology, 61(5), pp. 1783-1794. (doi: 10.1093/rheumatology/keab740) (PMID:34668515)
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Abstract
Spondyloarthritis (SpA) comprises a group of chronic inflammatory diseases with overlapping clinical, genetic and pathophysiological features including back pain, peripheral arthritis, psoriasis, enthesitis and dactylitis. Several cytokines are involved in the pathogenesis of SpA, variously contributing to each clinical manifestation. Many SpA-associated cytokines, including IL-23, IL-17, IL-6, type I/II interferon and tumour necrosis factor signal directly or indirectly via the Janus kinase (JAK)–signal transducer and activator of transcription pathway. JAK signalling also regulates development and maturation of cells of the innate and adaptive immune systems. Accordingly, disruption of this signalling pathway by small molecule oral JAK inhibitors can inhibit signalling implicated in SpA pathogenesis. Herein we discuss the role of JAK signalling in the pathogenesis of SpA and summarize the safety and efficacy of JAK inhibition by reference to relevant SpA clinical trials.
Item Type: | Articles |
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Additional Information: | This work was supported by AbbVie, who participated in the writing, review and approval of the article. |
Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | McInnes, Professor Iain |
Authors: | McInnes, I. B., Szekanecz, Z., McGonagle, D., Maksymowych, W. P., Pfeil, A., Lippe, R., Song, I.-H., Lertratanakul, A., Sornasse, T., Biljan, A., and Deodhar, A. |
College/School: | College of Medical Veterinary and Life Sciences > School of Infection & Immunity |
Research Centre: | College of Medical Veterinary and Life Sciences > School of Infection & Immunity > Centre for Immunobiology |
Journal Name: | Rheumatology |
Publisher: | Oxford University Press |
ISSN: | 1462-0324 |
ISSN (Online): | 1462-0332 |
Published Online: | 20 October 2021 |
Copyright Holders: | Copyright © 2021 The Authors |
First Published: | First published in Rheumatology 61(5): 1783-1794 |
Publisher Policy: | Reproduced under a Creative Commons License |
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