Retrospective, multicenter analysis comparing conventional with oncoplastic breast conserving surgery: oncological and surgical outcomes in women with high-risk breast cancer from the OPBC-01/iTOP2 study

Fitzal, F. et al. (2022) Retrospective, multicenter analysis comparing conventional with oncoplastic breast conserving surgery: oncological and surgical outcomes in women with high-risk breast cancer from the OPBC-01/iTOP2 study. Annals of Surgical Oncology, 29(2), pp. 1061-1070. (doi: 10.1245/s10434-021-10809-1) (PMID:34647202) (PMCID:PMC8724061)

Abstract

Introduction: Recent data suggest that margins ≥2 mm after breast-conserving surgery may improve local control in invasive breast cancer (BC). By allowing large resection volumes, oncoplastic breast-conserving surgery (OBCII; Clough level II/Tübingen 5-6) may achieve better local control than conventional breast conserving surgery (BCS; Tübingen 1-2) or oncoplastic breast conservation with low resection volumes (OBCI; Clough level I/Tübingen 3-4). Methods: Data from consecutive high-risk BC patients treated in 15 centers from the Oncoplastic Breast Consortium (OPBC) network, between January 2010 and December 2013, were retrospectively reviewed. Results: A total of 3,177 women were included, 30% of whom were treated with OBC (OBCI n = 663; OBCII n = 297). The BCS/OBCI group had significantly smaller tumors and smaller resection margins compared with OBCII (pT1: 50% vs. 37%, p = 0.002; proportion with margin <1 mm: 17% vs. 6%, p < 0.001). There were significantly more re-excisions due to R1 (“ink on tumor”) in the BCS/OBCI compared with the OBCII group (11% vs. 7%, p = 0.049). Univariate and multivariable regression analysis adjusted for tumor biology, tumor size, radiotherapy, and systemic treatment demonstrated no differences in local, regional, or distant recurrence-free or overall survival between the two groups. Conclusions: Large resection volumes in oncoplastic surgery increases the distance from cancer cells to the margin of the specimen and reduces reexcision rates significantly. With OBCII larger tumors are resected with similar local, regional and distant recurrence-free as well as overall survival rates as BCS/OBCI.

• Item Type: Articles
• Additional Information: Open access funding provided by Medical University of Vienna. No funding.
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Romics, Mr Laszlo and Morrow, Dr Elizabeth
• Authors: Fitzal, F., Bolliger, M., Dunkler, D., Geroldinger, A., Gambone, L., Heil, J., Riedel, F., de Boniface, J., Andre, C., Matrai, Z., Pukancsik, D., Paulinelli, R. R., Ostapenko, V., Burneckis, A., Ostapenko, A., Ostapenko, E., Meani, F., Harder, Y., Bonollo, M., Alberti, A. S. M., Tausch, C., Papassotiropoulos, B., Helfgott, R., Heck, D., Fehrer, H.-J., Acko, M., Schrenk, P., Trapp, E. K., Gunda, P.-T., Clara, P., Montagna, G., Ritter, M., Blohmer, J.-U., Steffen, S., Romics, L., Morrow, E., Lorenz, K., Fehr, M., and Weber, W. P.
• College/School: College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing
• Journal Name: Annals of Surgical Oncology
• Publisher: Springer
• ISSN: 1068-9265
• ISSN (Online): 1534-4681
• Published Online: 13 October 2021
• Copyright Holders: Copyright © 2021 The Authors
• First Published: First published in Annals of Surgical Oncology 29(2): 1061-1070
• Publisher Policy: Reproduced under a Creative Commons License