Identifying novel candidates and configurations for human helminth vaccines

Maizels, R. M. (2021) Identifying novel candidates and configurations for human helminth vaccines. Expert Review of Vaccines, 20(11), pp. 1389-1393. (doi: 10.1080/14760584.2021.1999810) (PMID:34720028) (PMCID:PMC8734949)

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Introduction: Human infections with helminth worm parasites are extraordinarily prevalent across tropical and subtropical parts of the world, and control relies primarily on drugs that offer short-term suppression of infection. There is an urgent need for new vaccines that would confer long-lived immunity, protecting children in particular and minimizing community transmission. Areas covered: This article discusses the development of helminth vaccines, from the first successful veterinary vaccines that demonstrated the feasibility of inducing protective immunity to helminths, to more recent initiatives to test human helminth antigens. The field has focussed primarily on evaluating individual antigens that could constitute targets amenable to antibody attack to inhibit parasite establishment. In a new direction, vaccines employing extracellular vesicles released by helminths have also given exciting results. Expert opinion: Taking into account the complex life cycles and sophisticated immune evasion strategies of many helminths, a combination of antigens and approaches designed to target essential functional pathways of the parasite will be required to achieve a high level of protection in future anti-helminth vaccines.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Maizels, Professor Rick
Authors: Maizels, R. M.
College/School:College of Medical Veterinary and Life Sciences > School of Infection & Immunity
Research Centre:College of Medical Veterinary and Life Sciences > School of Infection & Immunity > Centre for Immunobiology
Journal Name:Expert Review of Vaccines
Publisher:Taylor and Francis
ISSN (Online):1744-8395
Published Online:01 November 2021
Copyright Holders:Copyright © 2021 The Author
First Published:First published in Expert Review of Vaccines 2021
Publisher Policy:Reproduced under a Creative Commons License

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
308411Molecular and Cellular Interactions in Helminth InfectionsRichard MaizelsWellcome Trust (WELLCOTR)219530/Z/19/ZIII - Parasitology
170547The Wellcome Centre for Molecular Parasitology ( Core Support )Andrew WatersWellcome Trust (WELLCOTR)104111/Z/14/ZIII - Parasitology