Fornace, K. M. , Nuin, N. A., Betson, M., Grigg, M. J., William, T., Anstey, N. M., Yeo, T. W., Cox, J., Ying, L. T. and Drakeley, C. J. (2016) Asymptomatic and submicroscopic carriage of Plasmodium knowlesi malaria in household and community members of clinical cases in Sabah, Malaysia. Journal of Infectious Diseases, 213(5), pp. 784-787. (doi: 10.1093/infdis/jiv475) (PMID:26433222) (PMCID:PMC4747612)
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Abstract
Although asymptomatic carriage of human malaria species has been widely reported, the extent of asymptomatic, submicroscopic Plasmodium knowlesi parasitemia is unknown. In this study, samples were obtained from individuals residing in households or villages of symptomatic malaria cases with the aim of detecting submicroscopic P. knowlesi in this population. Four published molecular assays were used to confirm the presence of P. knowlesi. Latent class analysis revealed that the estimated proportion of asymptomatic individuals was 6.9% (95% confidence interval, 5.6%–8.4%). This study confirms the presence of a substantial number of asymptomatic monoinfections across all age groups; further work is needed to estimate prevalence in the wider community.
Item Type: | Articles |
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Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Fornace, Dr Kimberly |
Authors: | Fornace, K. M., Nuin, N. A., Betson, M., Grigg, M. J., William, T., Anstey, N. M., Yeo, T. W., Cox, J., Ying, L. T., and Drakeley, C. J. |
College/School: | College of Medical Veterinary and Life Sciences > School of Biodiversity, One Health & Veterinary Medicine |
Journal Name: | Journal of Infectious Diseases |
Publisher: | Oxford University Press |
ISSN: | 0022-1899 |
ISSN (Online): | 1537-6613 |
Published Online: | 03 October 2015 |
Copyright Holders: | Copyright © 2015 The Authors |
First Published: | First published in Journal of Infectious Diseases 213(5): 784-787 |
Publisher Policy: | Reproduced under a Creative Commons License |
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