Antifungal loaded calcium sulfate beads as a potential therapeutic in combating Candida auris

Butcher, M. C., Brown, J. L. , Hansom, D., Wilson-Van Os, R., Delury, C., Laycock, P. A. and Ramage, G. (2022) Antifungal loaded calcium sulfate beads as a potential therapeutic in combating Candida auris. Antimicrobial Agents and Chemotherapy, 66(1), e01713-21. (doi: 10.1128/AAC.01713-21) (PMID:34694875) (PMCID:PMC8765289)

Abstract

Candida auris provides a substantial global nosocomial threat clinically. With the recent emergence that the organism can readily colonize skin niches, it will likely continue to pose a risk in healthcare units, particularly to patients undergoing surgery. The purpose of this study was to investigate the efficacy of antifungal loaded calcium sulfate beads in combatting C. auris infection. We demonstrate that the CS-packed beads have the potential to interfere with planktonic and sessile C. auris.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Butcher, Mr Mark and Ramage, Professor Gordon and Hansom, Mr Donald and Brown, Dr Jason
• Authors: Butcher, M. C., Brown, J. L., Hansom, D., Wilson-Van Os, R., Delury, C., Laycock, P. A., and Ramage, G.
• College/School: College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing > Dental School
• Journal Name: Antimicrobial Agents and Chemotherapy
• Publisher: American Society for Microbiology
• ISSN: 0066-4804
• ISSN (Online): 1098-6596
• Published Online: 25 October 2021
• Copyright Holders: Copyright © 2021 Butcher et al.
• First Published: First published in Antimicrobial Agents and Chemotherapy 66(1): e01713-21
• Publisher Policy: Reproduced under a Creative Commons licence