Segref, A., Cabello, J., Clucas, C., Schnabel, R. and Johnstone, I. L. (2010) Fate specification and tissue-specific cell cycle control of the Caenorhabditis elegans intestine. Molecular Biology of the Cell, 21(5), pp. 725-738. (doi: 10.1091/mbc.E09-04-0268)
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Publisher's URL: http://dx.doi.org/10.1091/mbc.E09-04-0268
Abstract
Coordination between cell fate specification and cell cycle control in multicellular organisms is essential to regulate cell numbers in tissues and organs during development, and its failure may lead to oncogenesis. In mammalian cells, as part of a general cell cycle checkpoint mechanism, the F-box protein β-transducin repeat-containing protein (β-TrCP) and the Skp1/Cul1/F-box complex control the periodic cell cycle fluctuations in abundance of the CDC25A and B phosphatases. Here, we find that the Caenorhabditis elegans β-TrCP orthologue LIN-23 regulates a progressive decline of CDC-25.1 abundance over several embryonic cell cycles and specifies cell number of one tissue, the embryonic intestine. The negative regulation of CDC-25.1 abundance by LIN-23 may be developmentally controlled because CDC-25.1 accumulates over time within the developing germline, where LIN-23 is also present. Concurrent with the destabilization of CDC-25.1, LIN-23 displays a spatially dynamic behavior in the embryo, periodically entering a nuclear compartment where CDC-25.1 is abundant.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Johnstone, Professor Iain and Clucas, Dr Caroline |
| Authors: | Segref, A., Cabello, J., Clucas, C., Schnabel, R., and Johnstone, I. L. |
| Subjects: | Q Science > QH Natural history > QH301 Biology |
| College/School: | College of Medical Veterinary and Life Sciences > School of Life Sciences College of Medical Veterinary and Life Sciences > School of Infection & Immunity College of Medical Veterinary and Life Sciences > School of Molecular Biosciences |
| Journal Name: | Molecular Biology of the Cell |
| Journal Abbr.: | MBoC |
| Publisher: | American Society for Cell Biology |
| ISSN: | 1059-1524 |
| ISSN (Online): | 1939-4586 |
| Published Online: | 06 January 2010 |
| Copyright Holders: | Copyright © 2010 American Society for Cell Biology |
| First Published: | First published in Molecular Biology of the Cell 21(5):725-738 |
| Publisher Policy: | Reproduced in accordance with the copyright policy of the publisher. |
| Related URLs: |
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