McInnes, I. B. and Gravallese, E. M. (2021) Immune-mediated inflammatory disease therapeutics: past, present and future. Nature Reviews Immunology, 21(10), pp. 680-686. (doi: 10.1038/s41577-021-00603-1) (PMID:34518662) (PMCID:PMC8436867)
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Abstract
Immune-mediated inflammatory diseases are common and clinically diverse. Although they are currently incurable, the therapeutic armamentarium for immune-mediated inflammatory diseases has been transformed in the past two decades. We have moved from the wide application of broad-spectrum immune modulators to the routine use of agents with exquisite specificity, arising from monoclonal and molecular biotechnology and more recently from highly targeted medicinal chemistry. Here we describe key advances and lessons that drove this remarkable progress and thereafter reflect on the next steps in this ongoing journey.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | McInnes, Professor Iain |
| Authors: | McInnes, I. B., and Gravallese, E. M. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Infection & Immunity |
| Research Centre: | College of Medical Veterinary and Life Sciences > School of Infection & Immunity > Centre for Immunobiology |
| Journal Name: | Nature Reviews Immunology |
| Publisher: | Nature Research |
| ISSN: | 1474-1733 |
| ISSN (Online): | 1474-1741 |
| Published Online: | 13 September 2021 |
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