Pujol-Navarro, N., Al Qaraghuli, M. M., Kubiak-Ossowska, K., Alsaadi, M. M., Horne, G. A. , Soutar, R. L., Paspali, E., Ferro, V. A., Williams, M. T.S. and Mulheran, P. A. (2021) Multiple myeloma: therapeutic delivery of antibodies and aptamers. Therapeutic Delivery, 12(10), pp. 705-722. (doi: 10.4155/tde-2021-0041) (PMID:34569269)
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Abstract
Multiple myeloma is the second most common hematological malignancy in adults, accounting for 2% of all cancer-related deaths in the UK. Current chemotherapy-based regimes are insufficient, as most patients relapse and develop therapy resistance. This review focuses on current novel antibody- and aptamer-based therapies aiming to overcome current therapy limitations, as well as their respective limitations and areas of improvement. The use of computer modeling methods, as a tool to study and improve ligand-receptor alignments for the use of novel therapy development will also be discussed, as it has become a rapid, reliable and comparatively inexpensive method of investigation.
| Item Type: | Articles |
|---|---|
| Additional Information: | This research was funded by the BBSRC-funded DTP IBioIC, grant number BB/S507118/1. |
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Horne, Dr Gillian and Soutar, Dr Richard |
| Authors: | Pujol-Navarro, N., Al Qaraghuli, M. M., Kubiak-Ossowska, K., Alsaadi, M. M., Horne, G. A., Soutar, R. L., Paspali, E., Ferro, V. A., Williams, M. T.S., and Mulheran, P. A. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Cancer Sciences College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing |
| Journal Name: | Therapeutic Delivery |
| Publisher: | Future Sciences Group |
| ISSN: | 2041-5990 |
| ISSN (Online): | 2041-6008 |
| Published Online: | 27 September 2021 |
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