Serum anti-GM2 and anti-GalNAc-GD1a IgG antibodies are biomarkers for acute canine polyradiculoneuritis

Halstead, S.K. et al. (2022) Serum anti-GM2 and anti-GalNAc-GD1a IgG antibodies are biomarkers for acute canine polyradiculoneuritis. Journal of Small Animal Practice, 63(2), pp. 104-112. (doi: 10.1111/jsap.13439) (PMID:34791652)

[img] Text
253305.pdf - Published Version
Available under License Creative Commons Attribution.



Objectives: A previous single-country pilot study indicated serum anti-GM2 and anti-GA1 anti-glycolipid antibodies as potential biomarkers for acute canine polyradiculoneuritis. This study aims to validate these findings in a large geographically heterogenous cohort. Materials and Methods: Sera from 175 dogs clinically diagnosed with acute canine polyradiculoneuritis, 112 dogs with other peripheral nerve, cranial nerve or neuromuscular disorders and 226 neurologically normal dogs were screened for anti-glycolipid antibodies against 11 common glycolipid targets to determine the immunoglobulin G anti-glycolipid antibodies with the highest combined sensitivity and specificity for acute canine polyradiculoneuritis. Results: Anti-GM2 anti-glycolipid antibodies reached the highest combined sensitivity and specificity (sensitivity: 65.1%, 95% confidence interval 57.6 to 72.2%; specificity: 90.2%, 95% confidence interval 83.1 to 95.0%), followed by anti-GalNAc-GD1a anti-glycolipid antibodies (sensitivity: 61.7%, 95% confidence interval 54.1 to 68.9%; specificity: 89.3%, 95% confidence interval 82.0 to 94.3%) and these anti-glycolipid antibodies were frequently present concomitantly. Anti-GA1 anti-glycolipid antibodies were detected in both acute canine polyradiculoneuritis and control animals. Both for anti-GM2 and anti-GalNAc-GD1a anti-glycolipid antibodies, sex was found a significantly associated factor with a female to male odds ratio of 2.55 (P=0.0096) and 3.00 (P=0.0198), respectively. Anti-GalNAc-GD1a anti-glycolipid antibodies were more commonly observed in dogs unable to walk (odds ratio 4.56; P=0.0076). Clinical Significance: Anti-GM2 and anti-GalNAc-GD1a immunoglobulin G anti-glycolipid antibodies represent serum biomarkers for acute canine polyradiculoneuritis.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Penderis, Professor Jacques and Halstead, Dr Susan and Wessmann, Dr Annette and Gourlay, Mrs Dawn and Willison, Professor Hugh and Gutierrez Quintana, Mr Rodrigo and Freeman, Mr Paul and Jose-Lopez, Mr Roberto and Rupp, Dr Angie and Jackson, Dr Mark
Authors: Halstead, S.K., Gourlay, D.S., Penderis, J., Bianchi, E., Dondi, M., Wessmann, A., Musteata, M., Le Chevoir, M., Martinez-Anton, L., Bhatti, S.F.M., Volk, H., Mateo, I., Tipold, A., Ives, E., Pakozdy, A., Gutierrez-Quintana, R., Brocal, J., Whitehead, Z., Granger, N., Pazzi, P., Harcourt-Brown, T., José-López, R., Rupp, S., Schenk, H.C., Smith, P., Gandini, G., Menchetti, M., Mortera-Balsa, V., Rusbridge, C., Tauro, A., Cozzi, F., Deutschland, M., Tirrito, F., Freeman, P., Lowrie, M., Jackson, M.R., Willison, H.J., and Rupp, A.
College/School:College of Medical Veterinary and Life Sciences > School of Biodiversity, One Health & Veterinary Medicine
College of Medical Veterinary and Life Sciences > School of Cancer Sciences
College of Medical Veterinary and Life Sciences > School of Infection & Immunity
Research Centre:College of Medical Veterinary and Life Sciences > School of Infection & Immunity > Centre for Immunobiology
Journal Name:Journal of Small Animal Practice
ISSN (Online):1748-5827
Published Online:17 November 2021
Copyright Holders:Copyright © 2021 The Authors
First Published:First published in Journal of Small Animal Practice 63(2): 104-112
Publisher Policy:Reproduced under a Creative Commons License

University Staff: Request a correction | Enlighten Editors: Update this record

Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
174177Sensitivity and specificity of anti-ganglioside antibodies for the diagnosis of acute canine polyradiculoneuritis and geographic differences in sero-prevalenceAngelika Frances RuppPetsavers (PETSAVER)42869Vets - Veterinary Science and Education
165079The structural and functional diversity of anti-glycolipid antibody repertoires and their nerve binding domains in human autoimmune neuropathyHugh WillisonWellcome Trust (WELLCOTR)092805/Z/10/ZIII - Immunology
173549Pathophysiological factors in the diagnosis and treatment of the Guillain-Barre syndromesHugh WillisonWellcome Trust (WELLCOTR)202789/Z/16/ZIII - Immunology