Autophagy in hematopoiesis and leukemogenesis

Ianniciello, A. and Helgason, G. V. (2021) Autophagy in hematopoiesis and leukemogenesis. In: Rothermel, B. A. and Diwan, A. (eds.) Autophagy in Health and Disease. Second Edition. Academic Press: London, pp. 125-141. ISBN 9780128220030 (doi: 10.1016/B978-0-12-822003-0.00021-8)

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Maintaining cellular homeostasis, optimal cell function, and healthy organelles are key factors that enable a prompt response to any stressful condition that may arise throughout the life of an individual. Autophagy is a catalytic process that cells modulate to ensure cellular homeostasis by removing waste, replacing damaged and old organelles, and sustaining cell survival during low-nutrient conditions. As such, autophagy plays an important role in maintaining the cellular homeostasis of all hematopoietic lineages. This chapter describes the normal function of the hematopoietic system and the role of autophagy for each blood cell type, focusing on cell development and differentiation. Furthermore, we describe the role that autophagy plays in the four most common forms of leukemia and how leukemic cells may hijack this process to mitigate unfavorable conditions, such as metabolic stress or exposure to chemotherapeutics.

Item Type:Book Sections
Glasgow Author(s) Enlighten ID:Helgason, Professor Vignir and Ianniciello, Ms Angela
Authors: Ianniciello, A., and Helgason, G. V.
College/School:College of Medical Veterinary and Life Sciences > School of Cancer Sciences
Publisher:Academic Press
Published Online:24 September 2021

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