Cortes, S., Albuquerque, A. , Cabral, L. I. L., Lopes, L., Campino, L. and Cristiano, M. L.S. (2015) In vitro susceptibility of Leishmania infantum to artemisinin derivatives and selected trioxolanes. Antimicrobial Agents and Chemotherapy, 59(8), pp. 5032-5035. (doi: 10.1128/AAC.00298-15) (PMID:26014947) (PMCID:PMC4505222)
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Abstract
Leishmaniasis is among the world's most neglected diseases. Currently available drugs for treatment present drawbacks, urging the need for more effective, safer, and cheaper drugs. A small library of artemisinin-derived trioxanes and synthetic trioxolanes was tested against promastigote and intramacrophage amastigote forms of Leishmania infantum. The trioxolanes LC50 and LC95 presented the best activity and safety profiles, showing potential for further studies in the context of leishmanial therapy. Our results indicate that the compounds tested exhibit peroxide-dependent activity.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Albuquerque-Wendt, Ms Andreia |
| Authors: | Cortes, S., Albuquerque, A., Cabral, L. I. L., Lopes, L., Campino, L., and Cristiano, M. L.S. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Infection & Immunity |
| Journal Name: | Antimicrobial Agents and Chemotherapy |
| Publisher: | American Society for Microbiology |
| ISSN: | 0066-4804 |
| ISSN (Online): | 1098-6596 |
| Published Online: | 26 May 2015 |
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