Effect of an office-based intervention on visceral adipose tissue: the WorkACTIVE-P randomized controlled trial

Dorling, J. L. , Höchsmann, C., Tudor-Locke, C., Beyl, R. and Martin, C. K. (2021) Effect of an office-based intervention on visceral adipose tissue: the WorkACTIVE-P randomized controlled trial. Applied Physiology, Nutrition, and Metabolism, 46(2), pp. 117-125. (doi: 10.1139/apnm-2020-0175)

Abstract

Office-based activity reduces sedentariness, yet no randomized controlled trials (RCTs) have assessed how such activity influences visceral adipose tissue (VAT). This study examined the effect of an office-based, multicomponent activity intervention on VAT. The WorkACTIVE-P RCT enrolled sedentary office workers (body mass index: 31.4 (standard deviation (SD) 4.4) kg/m2) to an intervention (n = 20) or control (n = 20) group. For 3 months, the intervention group received an office-based pedal desk, further to an intervention promoting its use and increased walking. The control group maintained habitual activity. At baseline and follow-up, VAT, cardiometabolic disease risk markers, physical activity, and food intake were measured. Steps/day were not altered relative to control (P ≥ 0.51), but the pedal desk was utilized for 127 (SD 61) min/day. The intervention reduced VAT relative to control (−0.15 kg; 95% confidence interval (CI) = −0.29 to −0.01; P = 0.04). Moreover, the intervention decreased fasting glucose compared with control (−0.29 mmol/L; 95% CI = −0.51 to −0.06; P = 0.01), but no differences in other cardiometabolic disease markers or food intake were revealed (P ≥ 0.11). A multicomponent intervention decreased VAT in office workers who were overweight or obese. Though longer-term studies are needed, office-based, multicomponent activity regimens may lower cardiometabolic disease risk. Trial registered at ClinicalTrials.gov (NCT02561611).

• Item Type: Articles

Additional Information

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and Health (grants no. R21 OH010785), the Louisiana Clinical &
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• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Dorling, Dr James
• Authors: Dorling, J. L., Höchsmann, C., Tudor-Locke, C., Beyl, R., and Martin, C. K.
• College/School: College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing
• Journal Name: Applied Physiology, Nutrition, and Metabolism
• Publisher: NRC Research Press
• ISSN: 1715-5312
• ISSN (Online): 1715-5320
• Published Online: 15 January 2021