Paramyxoviruses from neotropical bats suggest a novel genus and nephrotropism

de Souza, W. M. et al. (2021) Paramyxoviruses from neotropical bats suggest a novel genus and nephrotropism. Infection, Genetics and Evolution, 95, 105041. (doi: 10.1016/j.meegid.2021.105041) (PMID:34411742)

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Paramyxoviruses have a broad host range and geographic distribution, including human pathogens transmitted by bats, such as Nipah and Hendra viruses. In this study, we combined high-throughput sequencing and molecular approaches to investigate the presence of paramyxoviruses in neotropical bats (Microchiroptera suborder) in Brazil. We discovered and characterized three novel paramyxoviruses in the kidney tissues of apparently healthy common vampire bats (D. rotundus) and Seba's short-tailed bats (C. perspicillata), which we tentatively named Kanhgág virus (KANV), Boe virus (BOEV), and Guató virus (GUATV). In this study, we classified these viruses as putative species into the Macrojêvirus genus, a newly proposed genus of the Orthoparamyxovirinae subfamily. Using RT-PCR, we detected these viruses in 20.9% (9 out of 43) of bats tested, and viral RNA was detected exclusively in kidney tissues. Attempts to isolate infectious virus were successful for KANV and GUATV. Our results expand the viral diversity, host range, and geographical distribution of the paramyxoviruses.

Item Type:Articles
Additional Information:Funding: This work was supported by the Fundação de Amparo à Pesquisa do Estado de São Paulo, Brazil (Grant number. 13/14929-1, and Scholarships No. 06/00572-0, 15/05778-5; 17/13981-0, 19/24251-9 and 18/09383-3) and by the CADDE/FAPESP Brazil-UK partnership grant (MR/S0195/1 and FAPESP 18/14389-0) ( NRF is supported by a Wellcome Trust and Royal Society Sir Henry Dale Fellowship (204311/Z/16/Z). PRM is supported by the Medical Research Council of the United Kingdom (MC_UU_12014/9). National Institutes of Health grant R24 AI120942.
Keywords:Paramyxovirus, virus discovery, paramyxoviridae, bat-borne diseases.
Glasgow Author(s) Enlighten ID:Murcia, Professor Pablo
Authors: de Souza, W. M., Fumagalli, M. J., Carrera, J. P., de Araujo, J., Cardoso, J. F., de Carvalho, C., Durigon, E. L., Queiroz, L. H., Faria, N. R., Murcia, P. R., and Figueiredo, L. T. M.
College/School:College of Medical Veterinary and Life Sciences > School of Infection & Immunity > Centre for Virus Research
Journal Name:Infection, Genetics and Evolution
ISSN (Online):1567-7257
Published Online:17 August 2021

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
172630Quinquennial Core FundsMassimo PalmariniMedical Research Council (MRC)MC_UU_12014/9III-MRC-GU CVR Support Services