Review on toxic effects of di(2-ethylhexyl) phthalate on zebrafish embryos

Kwan, W. S., Roy, V. A. L. and Yu, K. N. (2021) Review on toxic effects of di(2-ethylhexyl) phthalate on zebrafish embryos. Toxics, 9(8), 193. (doi: 10.3390/toxics9080193)

Abstract

Di(2-ethylhexyl) phthalate (DEHP) is widely used as a plasticizer in consumer products. People are continuously exposed to DEHP through ingestion, inhalation and dermal absorption. From epidemiological studies, DEHP has been shown to associate with various adverse health effects, such as reproductive abnormalities and metabolic diseases. Health concerns have been raised regarding DEHP exposures; therefore, relevant risk assessment has become necessary through toxicological testing of DEHP. In the past 10 years, an increasing number of DEHP toxicity studies have been using zebrafish embryos as an in vivo model due to their high fecundity, rapid embryonic development as well as optical transparency, which have now been established as an alternative of the more conventional rodent model. The aim of the present paper is to review the effects of acute (from embryo stage to ≤1 week) and chronic (from embryo stage to >1 week) DEHP exposures on zebrafish, which start from the embryonic stage, and to analyze acute and potential long-term effects induced by acute exposure and effects induced by chronic exposure of DEHP upon subjecting to exposures, starting from the embryonic stage to different developmental stages, with a view to facilitate risk assessments on DEHP exposures.

• Item Type: Articles
• Additional Information: This research was funded by the Innovation and Technology Fund from HKSAR (grant number UIM/371), and by the State Key Laboratory in Marine Pollution of the City University of Hong Kong (grant number IRF/0024).
• Keywords: Phthalate, di(2-ethylhexyl) phthalate (DEHP), mono-2-ethylhexyl phthalate (MEHP), zebrafish embryo, toxic effect.
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Vellaisamy, Professor Roy

Creator Roles

Roy, V. A.L.: Writing – review and editing, Supervision, Project administration, Funding acquisition

• Authors: Kwan, W. S., Roy, V. A. L., and Yu, K. N.
• College/School: College of Science and Engineering > School of Engineering > Electronics and Nanoscale Engineering
• Journal Name: Toxics
• Publisher: MDPI
• ISSN: 2305-6304
• ISSN (Online): 2305-6304
• Published Online: 21 August 2021
• Copyright Holders: Copyright © 2021 The Authors
• First Published: First published in Toxics 9(8): 193
• Publisher Policy: Reproduced under a Creative Commons License