Boland, E., Quondamatteo, F. and Van Agtmael, T. (2021) The role of basement membranes in cardiac biology and disease. Bioscience Reports, 41(8), BSR20204185. (doi: 10.1042/bsr20204185) (PMID:34382650) (PMCID:PMC8390786)
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Abstract
Basement membranes are highly specialised extracellular matrix structures that within the heart underlie endothelial cells and surround cardiomyocytes and vascular smooth muscle cells. They generate a dynamic and structurally supportive environment throughout cardiac development and maturation by providing physical anchorage to the underlying interstitium, structural support to the tissue, and by influencing cell behaviour and signalling. While this provides a strong link between basement membrane dysfunction and cardiac disease, the role of the basement membrane in cardiac biology remains under-researched and our understanding regarding the mechanistic interplay between basement membrane defects and their morphological and functional consequences remain important knowledge-gaps. In this review we bring together emerging understanding of basement membrane defects within the heart including in common cardiovascular pathologies such as contractile dysfunction and highlight some key questions that are now ready to be addressed.
| Item Type: | Articles |
|---|---|
| Keywords: | Biophysics, cell biology, biochemistry, molecular biology. |
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Quondamatteo, Prof Fabio and Boland, Miss Erin and Van Agtmael, Professor Tom |
| Authors: | Boland, E., Quondamatteo, F., and Van Agtmael, T. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing |
| Journal Name: | Bioscience Reports |
| Publisher: | Portland Press |
| ISSN: | 1573-4935 |
| ISSN (Online): | 1573-4935 |
| Published Online: | 12 August 2021 |
| Copyright Holders: | Copyright © 2021 The Authors |
| First Published: | First published in Bioscience Reports 41(8): BSR20204185 |
| Publisher Policy: | Reproduced under a Creative Commons licence |
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