The role of basement membranes in cardiac biology and disease

Boland, E., Quondamatteo, F. and Van Agtmael, T. (2021) The role of basement membranes in cardiac biology and disease. Bioscience Reports, 41(8), BSR20204185. (doi: 10.1042/bsr20204185) (PMID:34382650) (PMCID:PMC8390786)

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Basement membranes are highly specialised extracellular matrix structures that within the heart underlie endothelial cells and surround cardiomyocytes and vascular smooth muscle cells. They generate a dynamic and structurally supportive environment throughout cardiac development and maturation by providing physical anchorage to the underlying interstitium, structural support to the tissue, and by influencing cell behaviour and signalling. While this provides a strong link between basement membrane dysfunction and cardiac disease, the role of the basement membrane in cardiac biology remains under-researched and our understanding regarding the mechanistic interplay between basement membrane defects and their morphological and functional consequences remain important knowledge-gaps. In this review we bring together emerging understanding of basement membrane defects within the heart including in common cardiovascular pathologies such as contractile dysfunction and highlight some key questions that are now ready to be addressed.

Item Type:Articles
Keywords:Biophysics, cell biology, biochemistry, molecular biology.
Glasgow Author(s) Enlighten ID:Quondamatteo, Prof Fabio and Boland, Miss Erin and Van Agtmael, Professor Tom
Authors: Boland, E., Quondamatteo, F., and Van Agtmael, T.
College/School:College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health
College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing
Journal Name:Bioscience Reports
Publisher:Portland Press
ISSN (Online):1573-4935
Published Online:12 August 2021
Copyright Holders:Copyright © 2021 The Authors
First Published:First published in Bioscience Reports 41(8): BSR20204185
Publisher Policy:Reproduced under a Creative Commons licence

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
302164Collagen IV variants and their role in intracerebral haemorrhage in the general populationTom Van AgtmaelMedical Research Council (MRC)MR/R005567/1CAMS - Cardiovascular Science
172813Targeting intracellular pathways to dissect mechanisms of cerebrovascular disease.Tom Van AgtmaelBritish Heart Foundation (BHF)PG/15/92/31813Institute of Cardiovascular & Medical Sciences
300478Elucidation of molecular pathways underlying cardiac disease caused by Col4a1 mutationsTom Van AgtmaelHeart Research UK (HEARTRES)RG 2664/17/20CAMS - Cardiovascular Science