Hydrogen sulfide in ageing, longevity and disease

Wilkie, S. E., Borland, G., Carter, R. N., Morton, N. M. and Selman, C. (2021) Hydrogen sulfide in ageing, longevity and disease. Biochemical Journal, 478(19), pp. 3485-3504. (doi: 10.1042/BCJ20210517) (PMID:34613340) (PMCID:PMC8589328)

Abstract

Hydrogen sulfide (H2S) modulates many biological processes, including ageing. Initially considered a hazardous toxic gas, it is now recognised that H2S is produced endogenously across taxa and is a key mediator of processes that promote longevity and improve late-life health. In this review, we consider the key developments in our understanding of this gaseous signalling molecule in the context of health and disease, discuss potential mechanisms through which H2S can influence processes central to ageing and highlight the emergence of novel H2S-based therapeutics. We also consider the major challenges that may potentially hinder the development of such therapies.

• Item Type: Articles
• Additional Information: We acknowledge support through a MRC Precision Medicine Doctoral Training Program PhD studentship (to SEW, Ref: MR/N013166/1) and the BBSRC (to CS, Ref: BB/S014330/1).
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Selman, Professor Colin and Borland, Dr Gillian and Wilkie, Mr Stephen
• Authors: Wilkie, S. E., Borland, G., Carter, R. N., Morton, N. M., and Selman, C.
• College/School: College of Medical Veterinary and Life Sciences > School of Biodiversity, One Health & Veterinary Medicine; College of Medical Veterinary and Life Sciences > School of Infection & Immunity; College of Medical Veterinary and Life Sciences > School of Cancer Sciences
• Journal Name: Biochemical Journal
• Publisher: Portland Press
• ISSN: 0264-6021
• ISSN (Online): 1470-8728
• Copyright Holders: Copyright © 2021 The Authors
• First Published: First published in Biochemical Journal 478(19):3485-3504
• Publisher Policy: Reproduced under a Creative Commons licence

Project Code	Award No	Project Name	Principal Investigator	Funder's Name	Funder Ref	Lead Dept
304005		MRC Precision Medicine Training Grant	Morven Barlass	Medical Research Council (MRC)	MR/N013166/1-LGH/MS/MED25	CAMS - Cardiovascular Science
305154		Consolidating the role of RNA polymerase III in healthy ageing: from worms to flies to mice	Colin Selman	Biotechnology and Biological Sciences Research Council (BBSRC)	BB/S014330/1	Institute of Biodiversity, Animal Health and Comparative Medicine