Hydrogen sulfide in ageing, longevity and disease

Wilkie, S. E., Borland, G., Carter, R. N., Morton, N. M. and Selman, C. (2021) Hydrogen sulfide in ageing, longevity and disease. Biochemical Journal, 478(19), pp. 3485-3504. (doi: 10.1042/BCJ20210517) (PMID:34613340) (PMCID:PMC8589328)

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Hydrogen sulfide (H2S) modulates many biological processes, including ageing. Initially considered a hazardous toxic gas, it is now recognised that H2S is produced endogenously across taxa and is a key mediator of processes that promote longevity and improve late-life health. In this review, we consider the key developments in our understanding of this gaseous signalling molecule in the context of health and disease, discuss potential mechanisms through which H2S can influence processes central to ageing and highlight the emergence of novel H2S-based therapeutics. We also consider the major challenges that may potentially hinder the development of such therapies.

Item Type:Articles
Additional Information:We acknowledge support through a MRC Precision Medicine Doctoral Training Program PhD studentship (to SEW, Ref: MR/N013166/1) and the BBSRC (to CS, Ref: BB/S014330/1).
Glasgow Author(s) Enlighten ID:Selman, Professor Colin and Wilkie, Stephen and Borland, Dr Gillian
Authors: Wilkie, S. E., Borland, G., Carter, R. N., Morton, N. M., and Selman, C.
College/School:College of Medical Veterinary and Life Sciences
College of Medical Veterinary and Life Sciences > School of Infection & Immunity
College of Medical Veterinary and Life Sciences > School of Biodiversity, One Health & Veterinary Medicine
Journal Name:Biochemical Journal
Publisher:Portland Press
ISSN (Online):1470-8728
Copyright Holders:Copyright © 2021 The Authors
First Published:First published in Biochemical Journal 478(19):3485-3504
Publisher Policy:Reproduced under a Creative Commons licence

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
304005MRC Precision Medicine Training GrantMorven BarlassMedical Research Council (MRC)MR/N013166/1-LGH/MS/MED25CAMS - Cardiovascular Science
305154Consolidating the role of RNA polymerase III in healthy ageing: from worms to flies to miceColin SelmanBiotechnology and Biological Sciences Research Council (BBSRC)BB/S014330/1Institute of Biodiversity, Animal Health and Comparative Medicine