Cognitive impairment in sporadic cerebral small vessel disease: a systematic review and meta‐analysis

Hamilton, O. K.L. , Backhouse, E. V., Janssen, E., Jochems, A. C. C., Maher, C., Ritakari, T. E., Stevenson, A. J., Xia, L., Deary, I. J. and Wardlaw, J. M. (2021) Cognitive impairment in sporadic cerebral small vessel disease: a systematic review and meta‐analysis. Alzheimer's and Dementia, 17(4), pp. 665-685. (doi: 10.1002/alz.12221) (PMID:33185327)

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Abstract

This paper is a proposal for an update on the characterization of cognitive impairments associated with sporadic cerebral small vessel disease (SVD). We pose a series of questions about the nature of SVD-related cognitive impairments and provide answers based on a comprehensive review and meta-analysis of published data from 69 studies. Although SVD is thought primarily to affect executive function and processing speed, we hypothesize that SVD affects all major domains of cognitive ability. We also identify low levels of education as a potentially modifiable risk factor for SVD-related cognitive impairment. Therefore, we propose the use of comprehensive cognitive assessments and the measurement of educational level both in clinics and research settings, and suggest several recommendations for future research.

Item Type:Articles
Additional Information:OKLH is funded by the College of Medicine and Veterinary Medicine at the University of Edinburgh, and is supported by the Wellcome Trust through the Translational Neuroscience PhD program at the University of Edinburgh. JMW is supported by the Row Fogo Charitable Trust, Fondation Leducq (Perivascular Spaces Transatlantic Network of Excellence), and EU Horizon 2020 (SVDs@Target) and the MRC UK Dementia Research Institute at the University of Edinburgh. IJD is partially supported by grants that contribute to the Lothian Birth Cohorts (Age UK [MR/M01311/1], Medical Research Council [MR/R024065/1], and national Institutes of Health [1R01AG054628-01A1]). AS and TER are supported by funding from the Wellcome Trust 4-year PhD in Translational Neuroscience (108890/Z/15/Z).
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Hamilton, Dr Olivia
Authors: Hamilton, O. K.L., Backhouse, E. V., Janssen, E., Jochems, A. C. C., Maher, C., Ritakari, T. E., Stevenson, A. J., Xia, L., Deary, I. J., and Wardlaw, J. M.
College/School:College of Medical Veterinary and Life Sciences > School of Health & Wellbeing > MRC/CSO SPHSU
Journal Name:Alzheimer's and Dementia
Publisher:Wiley
ISSN:1552-5260
ISSN (Online):1552-5279
Published Online:13 November 2020
Copyright Holders:Copyright © 2020 The Authors
First Published:First published in Alzheimer's and Dementia 17(4): 665-685
Publisher Policy:Reproduced under a Creative Commons License

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