No influence of the fat mass and obesity-associated gene rs9939609 single nucleotide polymorphism on blood lipids in young males

Dorling, J. L. , Thackray, A. E., King, J. A., Pucci, A., Goltz, F. R., Batterham, R. L. and Stensel, D. J. (2020) No influence of the fat mass and obesity-associated gene rs9939609 single nucleotide polymorphism on blood lipids in young males. Nutrients, 12(12), 3857. (doi: 10.3390/nu12123857) (PMID:33348678) (PMCID:PMC7766231)

Abstract

The fat mass and obesity-associated gene (FTO) rs9939609 A-allele is linked to obesity and dyslipidemia, yet the independent influence of this polymorphism on blood lipids remains equivocal. We examined the influence of the FTO rs9939609 polymorphism on fasting and postprandial blood lipids in individuals homozygous for the risk A-allele or T-allele with similar anthropometric and demographic characteristics. 12 AA and 12 TT males consumed a standardized meal after fasting overnight. Blood samples were collected at baseline (−1.5 h), before the meal (0 h), and for five hours postprandially to measure lipid, glucose, and insulin concentrations. Time-averaged total area under the curve (TAUC) values (0–5 h) were calculated and compared between genotypes. Fasting triacylglycerol (TG), high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, total cholesterol, non-esterified fatty acid (NEFA), glucose, and insulin concentrations were similar between groups (p ≥ 0.293). TAUC for TG was similar in AAs and TTs (95% confidence interval (CI) −0.52 to 0.31 mmol/L/h; p = 0.606). Likewise, TAUC values were similar for NEFA (95% CI −0.04 to 0.03 mmol/L/h; p = 0.734), glucose (95% CI −0.41 to 0.44 mmol/L/h; p = 0.951), and insulin (95% CI −6.87 to 2.83 pmol/L/h; p = 0.395). Blood lipids are not influenced by the FTO rs9939609 polymorphism, suggesting the FTO-dyslipidemia link is mediated by adiposity and weight management is important in preventing FTO-related lipid variations.

• Item Type: Articles
• Additional Information: This work was supported by the National Institute for Health Research (NIHR) Leicester Biomedical Research Centre (to D.J.S.), the Rosetrees Trust (to R.L.B.), the Stoneygate Trust (to R.L.B.), the Robert Luff Foundation (to R.L.B.), and an NIHR Research Professorship (RP-2015-06-005) (to R.L.B.).
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Dorling, Dr James

Creator Roles

Dorling, J. L.: Conceptualization, Methodology, Formal analysis, Investigation, Data curation, Writing – original draft, Project administration

• Authors: Dorling, J. L., Thackray, A. E., King, J. A., Pucci, A., Goltz, F. R., Batterham, R. L., and Stensel, D. J.
• College/School: College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing
• Journal Name: Nutrients
• Publisher: MDPI
• ISSN: 2072-6643
• ISSN (Online): 2072-6643
• Published Online: 17 December 2020
• Copyright Holders: Copyright © 2020 The Authors
• First Published: First published in Nutrients 12(12): 3857
• Publisher Policy: Reproduced under a Creative Commons License