The role of dimerisation in the cellular trafficking of G-protein-coupled receptors

Milligan, G. (2010) The role of dimerisation in the cellular trafficking of G-protein-coupled receptors. Current Opinion in Pharmacology, 10(1), pp. 23-29. (doi: 10.1016/j.coph.2009.09.010) (PMID:19850521)

Abstract

The concept that G-protein-coupled receptors can exist as homomeric and/or heteromeric complexes is now well established. Despite this, how dynamic such interactions are and if this may be modulated during receptor trafficking remain topics of debate. Use of endoplasmic reticulum trapping strategies and the generation of asymmetric homomers have started to provide information on the contribution of protein–protein interactions to receptor maturation, cell surface delivery and ligand-mediated endocytosis. Although dimer/oligomer formation appears to be essential for cell surface delivery of class A and class C GPCRs, this may not be the case for class B receptors.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Milligan, Professor Graeme
• Authors: Milligan, G.
• Subjects: R Medicine > RS Pharmacy and materia medica; Q Science > QR Microbiology
• College/School: College of Medical Veterinary and Life Sciences > School of Psychology & Neuroscience
• Journal Name: Current Opinion in Pharmacology
• Publisher: Elsevier
• ISSN: 1471-4892
• ISSN (Online): 1471-4973
• Published Online: 21 October 2009
• Copyright Holders: Copyright © 2010 Elsevier
• First Published: First published in Current Opinion in Pharmacology 10(1):23-29
• Publisher Policy: Reproduced in accordance with the copyright policy of the publisher.

Related URLs

• PubMed

Project Code	Award No	Project Name	Principal Investigator	Funder's Name	Funder Ref	Lead Dept
24249	1	Quantitative Analysis of the Effects of Receptor and G-Protein Mutations and Polymorphisms on Signal Initiation	Graeme Milligan	Medical Research Council (MRC)	G9811527	Institute of Neuroscience and Psychology
24249	2	Quantitative Analysis of the Effects of Receptor and G-Protein Mutations and Polymorphisms on Signal Initiation	Graeme Milligan	Medical Research Council (MRC)	G9811527	Institute of Neuroscience and Psychology
38978	1	The quaternary structure of G-protein coupled receptors - implications for function drug design. Programme grant support renewal	Graeme Milligan	Medical Research Council (MRC)	G9811527	Institute of Neuroscience and Psychology
51063	1	The organisational structure of class A GPCRs: implications for function and drug design	Graeme Milligan	Medical Research Council (MRC)	G0900050	Institute of Neuroscience and Psychology
43705	1	Exploring the selectivity and consequences of GPCR homo and hetero dimerisation/oligomerisation using receptors activated solely by ......	Graeme Milligan	Biotechnology and Biological Sciences Research Council (BBSRC)	BB/E006302/1	Institute of Neuroscience and Psychology