Significant differences in rates of aseptic loosening between two variations of a popular total knee arthroplasty design

Brown, M., Ramasubbu, R., Jenkinson, M., Doonan, J. , Blyth, M. and Jones, B. (2021) Significant differences in rates of aseptic loosening between two variations of a popular total knee arthroplasty design. International Orthopaedics, 45(11), pp. 2859-2867. (doi: 10.1007/s00264-021-05151-w) (PMID:34392378)

Abstract

Purpose: The NexGen Legacy Posterior Stabilised (LPS) prosthesis (Zimmer Biomet, Warsaw, IN, USA) has augmentable and non-augmentable tibial baseplate options. We have noted an anecdotal increase in the number of cases requiring early revision for aseptic loosening since adopting the non-augmentable option. The purpose of this study was to ascertain our rates of aseptic tibial loosening for the two implant types within five years of implantation and to investigate the causes for any difference observed. Methods: A database search was performed for all patients who underwent primary total knee arthroplasty (TKA) using the NexGen LPS between 2009 and 2015. Kaplan–Meier curves were plotted to assess for differences in revision rates between cohorts. We collected and compared data on gender, age, body mass index, component alignment and cement mantle quality as these were factors thought to affect the likelihood of aseptic loosening. Results: Two thousand one hundred seventy-two TKAs were included with five year follow-up. There were 759 augmentable knees of which 14 were revised and 1413 non-augmentable knees of which 48 were revised. The overall revision rate at five years was 1.84% in the augmentable cohort and 3.4% in the non-augmentable cohort. The revision rate for aseptic loosening was 0.26% in the augmentable group and 1.42% in the non-augmentable group (p = 0.0241). Conclusions: We have identified increased rates of aseptic loosening in non-augmentable components. This highlights the effect that minor implant changes can have on outcomes. We recommend that clinicians remain alert to implant changes and publish their own results when important trends are observed.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Brown, Mr Michael and Jones, Mr Bryn and Blyth, Mr Mark and Doonan, Dr James and Ramasubbu, Mr Rohan
• Authors: Brown, M., Ramasubbu, R., Jenkinson, M., Doonan, J., Blyth, M., and Jones, B.
• College/School: College of Medical Veterinary and Life Sciences > School of Infection & Immunity; College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing
• Journal Name: International Orthopaedics
• Publisher: Springer
• ISSN: 0341-2695
• ISSN (Online): 1432-5195
• Published Online: 15 August 2021
• Copyright Holders: Copyright © 2021 The Authors
• First Published: First published in International Orthopaedics 45(11): 2859-2867
• Publisher Policy: Reproduced under a Creative Commons License