Drosophila larval models of invasive tumorigenesis for in vivo studies on tumour/peripheral host tissue interactions during cancer cachexia

Hodgson, J. A. , Parvy, J.-P., Yu, Y., Vidal, M. and Cordero, J. B. (2021) Drosophila larval models of invasive tumorigenesis for in vivo studies on tumour/peripheral host tissue interactions during cancer cachexia. International Journal of Molecular Sciences, 22(15), 8317. (doi: 10.3390/ijms22158317) (PMID:34361081) (PMCID:PMC8347517)

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Abstract

Cancer cachexia is a common deleterious paraneoplastic syndrome that represents an area of unmet clinical need, partly due to its poorly understood aetiology and complex multifactorial nature. We have interrogated multiple genetically defined larval Drosophila models of tumourigenesis against key features of human cancer cachexia. Our results indicate that cachectic tissue wasting is dependent on the genetic characteristics of the tumour and demonstrate that host malnutrition or tumour burden are not sufficient to drive wasting. We show that JAK/STAT and TNF-α/Egr signalling are elevated in cachectic muscle and promote tissue wasting. Furthermore, we introduce a dual driver system that allows independent genetic manipulation of tumour and host skeletal muscle. Overall, we present a novel Drosophila larval paradigm to study tumour/host tissue crosstalk in vivo, which may contribute to future research in cancer cachexia and impact the design of therapeutic approaches for this pathology.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Vidal, Dr Marcos and Hodgson, Joseph Alexander and Parvy, Dr Jean-Philippe and Yu, Dr Yachuan and Cordero, Professor Julia
Authors: Hodgson, J. A., Parvy, J.-P., Yu, Y., Vidal, M., and Cordero, J. B.
College/School:College of Medical Veterinary and Life Sciences > School of Cancer Sciences
Journal Name:International Journal of Molecular Sciences
Publisher:MDPI
ISSN:1661-6596
ISSN (Online):1422-0067
Published Online:02 August 2021
Copyright Holders:Copyright © 2021 The Authors
First Published:First published in International Journal of Molecular Sciences 22(15): 8317
Publisher Policy:Reproduced under a Creative Commons License

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
190860Regulation of stem cell function during tissue homeostasis and transformationJulia CorderoWellcome Trust (WELLCOTR)104103/Z/14/ZInstitute of Cancer Sciences