Circulating microRNAs as diagnostic markers in primary aldosteronism

MacKenzie, S. M. , Saunders, H., van Kralingen, J. C., Robertson, S. , Riddell, A. , Zennaro, M.-C. and Davies, E. (2021) Circulating microRNAs as diagnostic markers in primary aldosteronism. Cancers, 13(21), 5312. (doi: 10.3390/cancers13215312) (PMCID:PMC8582381)

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Primary aldosteronism (PA) is a common and highly treatable condition, usually resulting from adrenocortical tumorous growth or hyperplasia. PA is currently underdiagnosed owing to its complex and protracted diagnostic procedures. A simplified biomarker-based test would be highly valuable in reducing cardiovascular morbidity and mortality. Circulating microRNAs are emerging as potential biomarkers for a number of conditions due to their stability and accessibility. PA is known to alter microRNA expression in adrenocortical tissue; if these changes or their effects are mirrored in the circulating miRNA profile, then this could be exploited by a diagnostic test. However, the reproducibility of studies to identify biomarker-circulating microRNAs has proved difficult for other conditions due to a series of technical challenges. Therefore, any studies seeking to definitively identify circulating microRNA biomarkers of PA must address this in their design. To this end, we are currently conducting the circulating microRNA arm of the ongoing ENS@T-HT study. In this review article, we present evidence to support the utility of circulating microRNAs as PA biomarkers, describe the practical challenges to this approach and, using ENS@T-HT as an example, discuss how these might be overcome.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Robertson, Dr Stacy and Davies, Professor Eleanor and Van Kralingen, Ms Josie and MacKenzie, Dr Scott and Riddell, Dr Alexandra
Creator Roles:
MacKenzie, S. M.Conceptualization, Writing – original draft, Writing – review and editing
van Kralingen, J. C.Conceptualization
Robertson, S.Conceptualization
Riddell, A.Conceptualization
Davies, E.Conceptualization, Writing – review and editing
Authors: MacKenzie, S. M., Saunders, H., van Kralingen, J. C., Robertson, S., Riddell, A., Zennaro, M.-C., and Davies, E.
College/School:College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health
Journal Name:Cancers
ISSN (Online):2072-6694
Published Online:22 October 2021
Copyright Holders:Copyright © 2021 The Authors
First Published:First published in Cancers 13(21): 5312
Publisher Policy:Reproduced under a Creative Commons License

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
171764ENSAT-HFEleanor DaviesEuropean Commission (EC)633983Institute of Cardiovascular & Medical Sciences