Tunbridge, M. J. and Jardine, A. G. (2021) Atherosclerotic vascular disease associated with chronic kidney disease. Cardiology Clinics, 39(3), pp. 403-414. (doi: 10.1016/j.ccl.2021.04.011)
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Abstract
Cardiovascular risk increases as glomerular filtration rate (GFR) declines in progressive renal disease and is maximal in patients with end-stage renal disease requiring maintenance dialysis. Atherosclerotic vascular disease, for which hyperlipidemia is the main risk factor and lipid-lowering therapy is the key intervention, is common. However, the pattern of dyslipidemia changes with low GFR and the association with vascular events becomes less clear. While the pathophysiology and management of patients with early chronic kidney disease (CKD) is similar to the general population, advanced and end-stage CKD is characterized by a disproportionate increase in fatal events, ineffectiveness of statin therapy, and greatly increased risk associated with coronary interventions. The most effective strategies to reduce atherosclerotic cardiovascular disease in CKD are to slow the decline in renal function or to restore renal function by transplantation.
| Item Type: | Articles |
|---|---|
| Keywords: | Atherosclerosis, chronic kidney disease, risk factors, vascular disease. |
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Jardine, Professor Alan |
| Authors: | Tunbridge, M. J., and Jardine, A. G. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing |
| Journal Name: | Cardiology Clinics |
| Publisher: | Elsevier |
| ISSN: | 0733-8651 |
| ISSN (Online): | 1558-2264 |
| Published Online: | 09 July 2021 |
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