Olson, M. F. and Machesky, L. M. (2021) MICAL2 fine-tunes Arp2/3 for actin branching. Journal of Cell Biology, 220(8), e202106176. (doi: 10.1083/jcb.202106176) (PMID:34264264)
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Abstract
The ARP2/3 complex promotes branched actin networks, but the importance of specific subunit isoforms is unclear. In this issue, Galloni, Carra, et al. (2021. J. Cell Biol. https://doi.org/10.1083/jcb.202102043) show that MICAL2 mediates methionine oxidation of ARP3B, thus destabilizing ARP2/3 complexes and leading to disassembly of branched actin filaments.
Item Type: | Articles |
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Additional Information: | M.F. Olson is funded by grants from the Canadian Institutes of Health Research (PJT-169125), Natural Sciences and Engineering Research Council of Canada (RGPIN-2020-05388) and Canada Research Chairs Program (950-231665). L.M. Machesky is funded by Cancer Research UK core grant A17196. |
Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Machesky, Professor Laura and Olson, Professor Michael |
Authors: | Olson, M. F., and Machesky, L. M. |
College/School: | College of Medical Veterinary and Life Sciences > School of Cancer Sciences |
Journal Name: | Journal of Cell Biology |
Publisher: | Rockefeller University Press |
ISSN: | 0021-9525 |
ISSN (Online): | 1540-8140 |
Published Online: | 15 July 2021 |
Copyright Holders: | Copyright © 2021 Olson and Machesky |
First Published: | First published in Journal of Cell Biology 220(8): e202106176 |
Publisher Policy: | Reproduced under a Creative Commons License |
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