Use of intra-operative cytological assessment of mandibular marrow scrapings to predict resection margin status in patients with squamous cell carcinoma

Mahmood, S., Conway, D.I. and Ramesar, K. (2001) Use of intra-operative cytological assessment of mandibular marrow scrapings to predict resection margin status in patients with squamous cell carcinoma. Journal of Oral and Maxillofacial Surgery, 59(10), 1138 -1141. (doi: 10.1053/joms.2001.26710)

Abstract

Purpose: This study assessed the feasibility of intraoperative microscopic assessment of mandibular bone resection margins in patients undergoing segmental resection of mandible for treatment of squamous cell carcinoma. Patients and Methods: This prospective pilot study involved 7 consecutive patients undergoing segmental resection of mandible as part of surgical treatment of oral squamous cell carcinoma. Cytologic examination of smear/touch preparations of 35 bone marrow scrapings, including simulated positive margins, was performed. Results: [ldquo ]Malignant[rdquo ] excision margins produced a high cell yield, and it was easy to assign samples to malignant or benign categories on microscopic examination. All the simulated positive margins were easily identified. No false positive results were found. Conclusion: Cytologic examination of bone excision margin scrapings is a rapid, inexpensive, and accurate technique. This study confirms its feasibility and accuracy in cases of mandibular resection for squamous cell carcinoma. [copy ] 2001 American Association of Oral and Maxillofacial Surgeons.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Mahmood, Mr Shaukat and Conway, Professor David
• Authors: Mahmood, S., Conway, D.I., and Ramesar, K.
• Subjects: R Medicine > RK Dentistry
• College/School: College of Medical Veterinary and Life Sciences; College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing; College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing > Dental School
• Journal Name: Journal of Oral and Maxillofacial Surgery