Nutrient regulation of inflammatory signalling in obesity and vascular disease

Palmer, T. M. and Salt, I. P. (2021) Nutrient regulation of inflammatory signalling in obesity and vascular disease. Clinical Science, 135(13), pp. 1563-1590. (doi: 10.1042/CS20190768) (PMID:34231841)

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Despite obesity and diabetes markedly increasing the risk of developing cardiovascular diseases, the molecular and cellular mechanisms that underlie this association remain poorly characterised. In the last 20 years it has become apparent that chronic, low-grade inflammation in obese adipose tissue may contribute to the risk of developing insulin resistance and type 2 diabetes. Furthermore, increased vascular pro-inflammatory signalling is a key event in the development of cardiovascular diseases. Overnutrition exacerbates pro-inflammatory signalling in vascular and adipose tissues, with several mechanisms proposed to mediate this. In this article, we review the molecular and cellular mechanisms by which nutrients are proposed to regulate pro-inflammatory signalling in adipose and vascular tissues. In addition, we examine the potential therapeutic opportunities that these mechanisms provide for suppression of inappropriate inflammation in obesity and vascular disease.

Item Type:Articles
Additional Information:The laboratories of T.M.P. and I.P.S. have been supported recently by Ph.D. Studentships [grant numbers BDA09/0003948,BDA11/0004403]; and an equipment grant from Diabetes U.K. [grant number BDA11/0004309]; Project Grants from the BritishHeart Foundation (BHF) [grant numbers PG/12/1/29276, PG/13/82/30483]; and T.M.P.’s laboratory is currently supported by aproject grant from the Hull and East Riding Cardiac Trust Fund.
Glasgow Author(s) Enlighten ID:Salt, Dr Ian and Palmer, Dr Timothy
Authors: Palmer, T. M., and Salt, I. P.
College/School:College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health
College of Medical Veterinary and Life Sciences > School of Molecular Biosciences
Journal Name:Clinical Science
Publisher:Portland Press
ISSN (Online):1470-8736
Published Online:07 July 2021
Copyright Holders:Copyright © 2021 The Authors
First Published:First published in Clinical Science 135(13):1563-1590
Publisher Policy:Reproduced in accordance with the copyright policy of the publisher

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
169547Inhibition of endothelial mitogen-activated protein kinases by amp-activated protein kinaseIan SaltBritish Heart Foundation (BHF)PG/13/82/30483Institute of Cardiovascular & Medical Sciences