Palmer, T. M. and Salt, I. P. (2021) Nutrient regulation of inflammatory signalling in obesity and vascular disease. Clinical Science, 135(13), pp. 1563-1590. (doi: 10.1042/CS20190768) (PMID:34231841)
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Abstract
Despite obesity and diabetes markedly increasing the risk of developing cardiovascular diseases, the molecular and cellular mechanisms that underlie this association remain poorly characterised. In the last 20 years it has become apparent that chronic, low-grade inflammation in obese adipose tissue may contribute to the risk of developing insulin resistance and type 2 diabetes. Furthermore, increased vascular pro-inflammatory signalling is a key event in the development of cardiovascular diseases. Overnutrition exacerbates pro-inflammatory signalling in vascular and adipose tissues, with several mechanisms proposed to mediate this. In this article, we review the molecular and cellular mechanisms by which nutrients are proposed to regulate pro-inflammatory signalling in adipose and vascular tissues. In addition, we examine the potential therapeutic opportunities that these mechanisms provide for suppression of inappropriate inflammation in obesity and vascular disease.
| Item Type: | Articles |
|---|---|
| Additional Information: | The laboratories of T.M.P. and I.P.S. have been supported recently by Ph.D. Studentships [grant numbers BDA09/0003948,BDA11/0004403]; and an equipment grant from Diabetes U.K. [grant number BDA11/0004309]; Project Grants from the BritishHeart Foundation (BHF) [grant numbers PG/12/1/29276, PG/13/82/30483]; and T.M.P.’s laboratory is currently supported by aproject grant from the Hull and East Riding Cardiac Trust Fund. |
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Salt, Dr Ian and Palmer, Dr Timothy |
| Authors: | Palmer, T. M., and Salt, I. P. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health College of Medical Veterinary and Life Sciences > School of Molecular Biosciences |
| Journal Name: | Clinical Science |
| Publisher: | Portland Press |
| ISSN: | 0143-5221 |
| ISSN (Online): | 1470-8736 |
| Published Online: | 07 July 2021 |
| Copyright Holders: | Copyright © 2021 The Authors |
| First Published: | First published in Clinical Science 135(13):1563-1590 |
| Publisher Policy: | Reproduced in accordance with the copyright policy of the publisher |
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