Validation of a model of regulation in the tryptophan operon against multiple experiment data using global optimisation

Kim, J.-R., Kim, J.-S., Postlethwaite, I., Heslop-Harrison, P. and Bates, D.G. (2009) Validation of a model of regulation in the tryptophan operon against multiple experiment data using global optimisation. In: ICCAS-SICE International Joint Conference 2009: Fukuoka International Congress Center, Fukuoka, Japan, August 18-21, 2009. Society of Instrument and Control Engineers / IEEE Computer Society: Fukuoka, Japan, pp. 209-211. ISBN 9784907764340

Abstract

This paper is concerned with validating a mathematical model of regulation in the tryptophan operon using global optimization. Although a number of models for this biochemical network are proposed, in many cases only qualitative agreement between the model output and experimental data was demonstrated, since very little information is currently available to guide the selection of parameter values for the models. This paper presents a model validating method using both multiple experimental data and global optimization.

• Item Type: Book Sections
• Keywords: Model Validation, Gloal Optimization, tryptophan regulation, parameter identification
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Kim, Dr Jongrae
• Authors: Kim, J.-R., Kim, J.-S., Postlethwaite, I., Heslop-Harrison, P., and Bates, D.G.
• Subjects: Q Science > QA Mathematics
• College/School: College of Science and Engineering > School of Engineering > Biomedical Engineering
• Publisher: Society of Instrument and Control Engineers / IEEE Computer Society
• ISBN: 9784907764340
• Copyright Holders: Copyright © 2009 IEEE Computer Society
• Publisher Policy: Reproduced in accordance with the copyright policy of the publisher.