Johnstone, M. S., Lynch, G., Park, J. , McSorley, S. and Edwards, J. (2021) Novel methods of risk stratifying patients for metachronous, pre-malignant colorectal polyps: a systematic review. Critical Reviews in Oncology/Haematology, 164, 103421. (doi: 10.1016/j.critrevonc.2021.103421) (PMID:34246774)
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Abstract
Introduction: Despite conventional measures of future polyp risk (histology, dysplasia, size, number), surveillance places a burden on patients and colonoscopy services. We aimed to review novel risk stratification techniques. Methods: A systematic literature review was performed for studies using genomics, transcriptomics, IHC or microbiome as markers of metachronous polyp risk. Results: 4165 papers underwent title, 303 abstract and 215 full paper review. 25 papers were included. 49 mutations/ SNPs/ haplotypes in 23 genes/ chromosomal regions (KRAS, APC, EGFR, COX1/2, IL23R, DRD2, CYP2C9/24A1/7A1, UGT1A6, ODC, ALOX12/15, PGDH, SRC, IGSF5, KCNS3, EPHB1/ KY, FAM188b, 3p24.1, 9q33.2, 13q33.2) correlated with metachronous adenoma / advanced adenoma risk. Expression levels of 6 proteins correlated with metachronous adenoma (p53, β-catenin, COX2, Adnab-9, ALDH1A1) or sessile serrated polyp (ANXA10) risk. Conclusion: Although genomic and IHC markers correlated with metachronous polyp risk, it seems likely that a panel of novel markers will be required to refine this risk.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Park, Mr James and Johnstone, Mark and Lynch, Dr Gerard and Edwards, Professor Joanne and McSorley, Dr Stephen |
| Authors: | Johnstone, M. S., Lynch, G., Park, J., McSorley, S., and Edwards, J. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Cancer Sciences College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing |
| Journal Name: | Critical Reviews in Oncology/Haematology |
| Publisher: | Elsevier |
| ISSN: | 1040-8428 |
| ISSN (Online): | 1879-0461 |
| Published Online: | 09 July 2021 |
| Copyright Holders: | Copyright © 2021 Elsevier B.V. |
| First Published: | First published in Critical Reviews in Oncology/Haematology 164: 103421 |
| Publisher Policy: | Reproduced in accordance with the publisher copyright policy |
University Staff: Request a correction | Enlighten Editors: Update this record
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