Remote history of VTE is associated with severe COVID-19 in middle and older age: UK Biobank cohort study

Anderson, J. J. et al. (2021) Remote history of VTE is associated with severe COVID-19 in middle and older age: UK Biobank cohort study. Journal of Thrombosis and Haemostasis, 19(10), pp. 2533-2538. (doi: 10.1111/jth.15452) (PMID:34242477) (PMCID:PMC8420476)

Abstract

Background: Venous thromboembolism (VTE) is a common, life-threatening complication of COVID-19 infection. COVID-19 risk-prediction models include a history of venous thromboembolism. However, it is unclear whether remote history (>9 years previously) of VTE also confers increased risk of COVID-19. Objectives: To investigate possible association between VTE and COVID-19 severity, independent of other risk factors. Methods: Cohort study of UK Biobank participants recruited between 2006-2010. Baseline data, including history of VTE, were linked to COVID-19 test results, COVID-19 related hospital admissions and COVID-19 deaths. The risk of COVID-19 hospitalisation or death was compared for participants with a remote history VTE versus without. Poisson regression models were run univariately then adjusted stepwise for socio-demographic, lifestyle and comorbid covariates. Results: After adjustment for socio-demographic and lifestyle confounders and comorbid conditions, remote history of VTE was associated with non-fatal community (RR 1.61, 95% CI 1.02-2.54, p=0.039), non-fatal hospitalised (RR 1.52, 95% CI 1.06-2.17, p=0.024) and severe (hospitalised or fatal) (RR 1.40, 95% CI 1.04-1.89, p=0.025) COVID-19. Associations with remote history of VTE were stronger among men (severe COVID-19: RR 1.68, 95% CI 1.14-2.42, p=0.009) than for women (severe COVID-19: RR 1.07, 95% CI 0.66-1.74, p=0.786). Conclusion: Our findings support inclusion of remote history of VTE in COVID-19 risk-prediction scores, and consideration of sex-specific risk scores.

• Item Type: Articles
• Additional Information: SVK is funded from a NRS Senior Clinical Fellowship (SCAF/15/02), the Medical Research Council (MC_UU_00022/2) and the Scottish Government Chief Scientist Office (SPHSU17). CLN is funded by the Medical Research Council (MR/R024774/1). ED is funded by the Medical Research Council (MC_UU_12017/13) and the Scottish Government Chief Scientist Office (SPHSU13). CB and NS are supported by the British Heart Foundation (RE/18/6134217).
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Hastie, Dr Claire and Gill, Professor Jason and Demou, Dr Evangelia and Ho, Dr Frederick and Welsh, Professor Paul and Anderson, Dr Jana and Niedzwiedz, Dr Claire and Katikireddi, Professor Vittal and Berry, Professor Colin and Celis, Dr Carlos and Gray, Professor Stuart and Iliodromiti, Dr Stamatina and Pell, Professor Jill and Mackay, Professor Daniel and Cleland, Professor John and Sattar, Professor Naveed and Pellicori, Dr Pierpaolo and Lyall, Dr Donald
• Authors: Anderson, J. J., Ho, F. K., Niedzwiedz, C. L., Katikireddi, V., Celis-Morales, C., Iliodromiti, S., Welsh, P., Pellicori, P., Demou, E., Hastie, C. E., Lyall, D. M., Gray, S. R., Forbes, J. F., Gill, J. M.R., Mackay, D. F., Berry, C., Cleland, J. G.F., Sattar, N., and Pell, J. P.
• College/School: College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health; College of Medical Veterinary and Life Sciences > School of Health & Wellbeing > General Practice and Primary Care; College of Medical Veterinary and Life Sciences > School of Health & Wellbeing > MRC/CSO SPHSU; College of Medical Veterinary and Life Sciences > School of Health & Wellbeing > Public Health; College of Medical Veterinary and Life Sciences > School of Health & Wellbeing > Robertson Centre; College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing
• Journal Name: Journal of Thrombosis and Haemostasis
• Publisher: Wiley
• ISSN: 1538-7933
• ISSN (Online): 1538-7836
• Published Online: 09 July 2021
• Copyright Holders: Copyright © 2021 The Authors
• First Published: First published in Journal of Thrombosis and Haemostasis 19(10): 2533-2538
• Publisher Policy: Reproduced under a Creative Commons License

Project Code	Award No	Project Name	Principal Investigator	Funder's Name	Funder Ref	Lead Dept
304823002	1	Inequalities in health	Alastair Leyland	Medical Research Council (MRC)	MC_UU_00022/2	HW - MRC/CSO Social and Public Health Sciences Unit
304823007	1	Inequalities in health	Alastair Leyland	Office of the Chief Scientific Adviser (CSO)	SPHSU17	HW - MRC/CSO Social and Public Health Sciences Unit
172690		Understanding the impacts of welfare policy on health: A novel data linkage study	Srinivasa Katikireddi	Office of the Chief Scientific Adviser (CSO)	SCAF/15/02	SHW - Public Health