Characteristics of early-onset vs late-onset colorectal cancer

Zaborowski, A. M. et al. (2021) Characteristics of early-onset vs late-onset colorectal cancer. JAMA Surgery, 156(9), pp. 865-874. (doi: 10.1001/jamasurg.2021.2380) (PMID:34190968)

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Importance The incidence of early-onset colorectal cancer (younger than 50 years) is rising globally, the reasons for which are unclear. It appears to represent a unique disease process with different clinical, pathological, and molecular characteristics compared with late-onset colorectal cancer. Data on oncological outcomes are limited, and sensitivity to conventional neoadjuvant and adjuvant therapy regimens appear to be unknown. The purpose of this review is to summarize the available literature on early-onset colorectal cancer. Observations Within the next decade, it is estimated that 1 in 10 colon cancers and 1 in 4 rectal cancers will be diagnosed in adults younger than 50 years. Potential risk factors include a Westernized diet, obesity, antibiotic usage, and alterations in the gut microbiome. Although genetic predisposition plays a role, most cases are sporadic. The full spectrum of germline and somatic sequence variations implicated remains unknown. Younger patients typically present with descending colonic or rectal cancer, advanced disease stage, and unfavorable histopathological features. Despite being more likely to receive neoadjuvant and adjuvant therapy, patients with early-onset disease demonstrate comparable oncological outcomes with their older counterparts. Conclusions and Relevance The clinicopathological features, underlying molecular profiles, and drivers of early-onset colorectal cancer differ from those of late-onset disease. Standardized, age-specific preventive, screening, diagnostic, and therapeutic strategies are required to optimize outcomes.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Roxburgh, Professor Campbell and Knight, Miss Katrina
Authors: Zaborowski, A. M., Abdile, A., Adamina, M., Aigner, F., d’Allens, L., Allmer, C., Álvarez, A., Anula, R., Andric, M., Atallah, S., Bach, S., Bala, M., Barussaud, M., Bausys, A., Bebington, B., Beggs, A., Bellolio, F., Bennett, M.-R., Berdinskikh, A., Bevan, V., Biondo, S., Bislenghi, G., Bludau, M., Boutall, A., Brouwer, N., Brown, C., Bruns, C., Buchanan, D. D., Buchwald, P., Burger, J. W. A., Burlov, N., Campanelli, M., Capdepont, M., Carvello, M., Chew, H.-H., Christoforidis, D., Clark, D., Climent, M., Cologne, K. G., Contreras, T., Croner, R., Daniels, I. R., Dapri, G., Davies, J., Delrio, P., Denost, Q., Deutsch, M., Dias, A., D’Hoore, A., Drozdov, E., Duek, D., Dunlop, M., Dziki, A., Edmundson, A., Efetov, S., El-Hussuna, A., Elliot, B., Emile, S., Espin, E., Evans, M., Faes, S., Faiz, O., Fleming, F., Foppa, C., Fowler, G., Frasson, M., Figueiredo, N., Forgan, T., Frizelle, F., Gadaev, S., Gellona, J., Glyn, T., Gong, J., Goran, B., Greenwood, E., Guren, M. G., Guillon, S., Gutlic, I., Hahnloser, D., Hampel, H., Hanly, A., Hasegawa, H., Iversen, L. H., Hill, A., Hill, J., Hoch, J., Hoffmeister, M., Hompes, R., Hurtado, L., Iaquinandi, F., Imbrasaite, U., Islam, R., Jafari, M. D., Kanemitsu, Y., Karachun, A., Karimuddin, A. A., Keller, D. S., Kelly, J., Kennelly, R., Khrykov, G., Kocian, P., Koh, C., Kok, N., Knight, K. A., Knol, J., Kontovounisios, C., Korner, H., Krivokapic, Z., Kronberger, I., Kroon, H. M., Kryzauskas, M., Kural, S., Kusters, M., Lakkis, Z., Lankov, T., Larson, D., Lázár, G., Lee, K.-Y., Lee, S. H., Lefèvre, J. H., Lepisto, A., Lieu, C., Loi, L., Lynch, C., Maillou-Martinaud, H., Maroli, A., Martin, S., Martling, A., Matzel, K. E., Mayol, J., McDermott, F., Meurette, G., Millan, M., Mitteregger, M., Moiseenko, A., Monson, J. R. T., Morarasu, S., Moritani, K., Möslein, G., Munini, M., Nahas, C., Nahas, S., Negoi, I., Novikova, A., Ocares, M., Okabayashi, K., Olkina, A., Oñate-Ocaña, L., Otero, J., Ozen, C., Pace, U., São Julião, G. P., Panaiotti, L., Panis, Y., Papamichael, D., Park, J., Patel, S., Patrón Uriburu, J. C., Pera, M., Perez, R. O., Petrov, A., Pfeffer, F., Phang, P. T., Poskus, T., Pringle, H., Proud, D., Raguz, I., Rama, N., Rasheed, S., Raval, M. J., Rega, D., Reissfelder, C., Reyes Meneses, J. C., Ris, F., Riss, S., Rodriguez-Zentner, H., Roxburgh, C. S., Saklani, A., Salido, A. J., Sammour, T., Saraste, D., Schneider, M., Seishima, R., Sekulic, A., Seppala, T., Sheahan, K., Shine, R., Shlomina, A., Sica, G. S., Singnomklao, T., Siragusa, L., Smart, N., Solis, A., Spinelli, A., Staiger, R. D., Stamos, M. J., Steele, S., Sunderland, M., Tan, K.-K., Tanis, P. J., Tekkis, P., Teklay, B., Tengku, S., Jiménez-Toscano, M., Tsarkov, P., Turina, M., Ulrich, A., Vailati, B. B., van Harten, M., Verhoef, K., Warrier, S., Wexner, S., de Wilt, H., Weinberg, B. A., Wells, C., Wolthuis, A., Xynos, E., You, N., Zakharenko, A., Zeballos, J., and Winter, D. C.
College/School:College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing
College of Medical Veterinary and Life Sciences > School of Cancer Sciences
Journal Name:JAMA Surgery
Publisher:American Medical Association
ISSN (Online):2168-6262
Published Online:30 June 2021

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