TMTHSI, a superior 7-membered ring alkyne containing reagent for strain-promoted azide-alkyne cycloaddition reactions

Weterings, J., Rijcken, C. J.F., Veldhuis, H., Meulemans, T., Hadavi, D., Timmers, M., Honing, M., Ippel, H. and Liskamp, R. M.J. (2020) TMTHSI, a superior 7-membered ring alkyne containing reagent for strain-promoted azide-alkyne cycloaddition reactions. Chemical Science, 11(33), pp. 9011-9016. (doi: 10.1039/D0SC03477K) (PMID:34123155) (PMCID:PMC8163418)

Abstract

We describe the development of TMTH-SulfoxImine (TMTHSI) as a superior click reagent. This reagent combines a great reactivity, with small size and low hydrophobicity and compares outstandingly with existing click reagents. TMTHSI can be conveniently functionalized with a variety of linkers allowing attachment of a diversity of small molecules and (peptide, nucleic acid) biologics.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Liskamp, Professor Robert
• Authors: Weterings, J., Rijcken, C. J.F., Veldhuis, H., Meulemans, T., Hadavi, D., Timmers, M., Honing, M., Ippel, H., and Liskamp, R. M.J.
• College/School: College of Science and Engineering > School of Chemistry
• Journal Name: Chemical Science
• Publisher: Royal Society of Chemistry
• ISSN: 2041-6520
• ISSN (Online): 2041-6520
• Published Online: 10 August 2020
• Copyright Holders: Copyright © 2020 The Royal Society of Chemistry
• First Published: First published in Chemical Science 11(33): 9011-9016
• Publisher Policy: Reproduced under a Creative Commons License