Pathogenesis of musculoskeletal deficits in children and adults with inflammatory bowel disease

Steell, L. , Gray, S. R. , Russell, R. K., MacDonald, J. , Seenan, J. P. , Wong, S. C. and Gaya, D. R. (2021) Pathogenesis of musculoskeletal deficits in children and adults with inflammatory bowel disease. Nutrients, 13(8), 2899. (doi: 10.3390/nu13082899)

Abstract

Musculoskeletal deficits are among the most commonly reported extra-intestinal manifestations and complications of inflammatory bowel disease (IBD), especially in those with Crohn’s disease. The adverse effects of IBD on bone and muscle are multifactorial, including the direct effects of underlying inflammatory disease processes, nutritional deficits, and therapeutic effects. These factors also indirectly impact bone and muscle by interfering with regulatory pathways. Resultantly, individuals with IBD are at increased risk of osteoporosis and sarcopenia and associated musculoskeletal morbidity. In paediatric IBD, these factors may contribute to suboptimal bone and muscle accrual. This review evaluates the main pathogenic factors associated with musculoskeletal deficits in children and adults with IBD and summarises the current literature and understanding of the musculoskeletal phenotype in these patients.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Russell, Dr Richard and Gaya, Mr Daniel and Wong, Dr Jarod and Seenan, Dr John and Steell, Mr Lewis and Gray, Professor Stuart and Macdonald, Dr Jonathan

Creator Roles

Steell, L.: Conceptualization, Writing – original draft, Data curation, Writing – review and editing
Gray, S. R.: Writing – review and editing
Russell, R. K.: Writing – review and editing
MacDonald, J.: Writing – review and editing
Seenan, J. P.: Writing – review and editing
Wong, S. C.: Conceptualization, Writing – original draft, Data curation, Writing – review and editing, Supervision
Gaya, D. R.: Conceptualization, Writing – original draft, Data curation, Writing – review and editing, Supervision

• Authors: Steell, L., Gray, S. R., Russell, R. K., MacDonald, J., Seenan, J. P., Wong, S. C., and Gaya, D. R.
• College/School: College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health; College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing
• Journal Name: Nutrients
• Publisher: MDPI
• ISSN: 2072-6643
• ISSN (Online): 2072-6643
• Published Online: 23 August 2021
• Copyright Holders: Copyright © 2021 The Authors
• First Published: First published in Nutrients 13(8): 2899
• Publisher Policy: Reproduced under a Creative Commons License