Review of emerging nanotechnology in bone regeneration: progress, challenges, and perspectives

Hajiali, H., Ouyang, L., Llopis-Hernandez, V. , Dobre, O. and Rose, F. R. A. J. (2021) Review of emerging nanotechnology in bone regeneration: progress, challenges, and perspectives. Nanoscale, 13(23), pp. 10266-10280. (doi: 10.1039/D1NR01371H) (PMID:34085085)

Abstract

The application of nanotechnology to regenerative medicine has increased over recent decades. The development of materials that can influence biology at the nanoscale has gained interest as our understanding of the interactions between cells and biomaterials at the nanoscale has grown. Materials that are either nanostructured or influence the nanostructure of the cellular microenvironment have been developed and shown to have advantages over their microscale counterparts. There are several reviews which have been published that discuss how nanomaterials have been used in regenerative medicine, particularly in bone regeneration. Most of these studies have explored this concept in specific areas, such as the application of glass-based nanocomposites, nanotechnology for targeted drug delivery to stimulate bone repair, and the progress in nanotechnology for the treatment of osteoporosis. In this review paper, the impact of nanotechnology in biomaterials development for bone regeneration will be discussed highlighting specifically, nanostructured materials that influence mechanical properties, biocompatibility, and osteoinductivity.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Llopis-Hernandez, Dr Virginia and Dobre, Dr Oana
• Authors: Hajiali, H., Ouyang, L., Llopis-Hernandez, V., Dobre, O., and Rose, F. R. A. J.
• College/School: College of Medical Veterinary and Life Sciences > School of Molecular Biosciences; College of Science and Engineering > School of Engineering > Biomedical Engineering
• Journal Name: Nanoscale
• Publisher: Royal Society of Chemistry
• ISSN: 2040-3364
• ISSN (Online): 2040-3372
• Published Online: 28 May 2021
• Copyright Holders: Copyright © 2021 The Royal Society of Chemistry
• First Published: First published in Nanoscale 13(23): 10266-10280
• Publisher Policy: Reproduced under a Creative Commons License