Association of fatal myocardial infarction with past level of physical activity: a pooled analysis of cohort studies

Wadt Hansen, K. et al. (2021) Association of fatal myocardial infarction with past level of physical activity: a pooled analysis of cohort studies. European Journal of Preventive Cardiology, 28(14), pp. 1590-1598. (doi: 10.1093/eurjpc/zwaa146) (PMID:33564885)

Abstract

Aims: To assess the association between past level of physical activity (PA) and risk for death during the acute phase of myocardial infarction (MI) in a pooled analysis of cohort studies. Methods and results: European cohorts including participants with a baseline assessment of PA, conventional cardiovascular (CV) risk factors, and available follow-up on MI and death were eligible. Patients with an incident MI were included. Leisure-time PA was grouped as sedentary (<7 MET-hours), low (7–16 MET-hours), moderate (16.1–32 MET-hours), or high (>32 MET-hours) based on calculated net weekly energy expenditure. The main outcome measures were instant and 28-day case fatality of MI. Pooled odds ratios (ORs) with 95% confidence intervals (CIs) were calculated using multivariate random-effects models. Adjustments for age, sex, CV risk factors, alcohol consumption, and socioeconomic status were made. From 10 cohorts including a total of 1 495 254 participants, 28 140 patients with an incident MI comprised the study population. A total of 4976 (17.7%) died within 28 days—of these 3101 (62.3%) were classified as instant fatal MI. Compared with sedentary individuals, those with a higher level of PA had lower adjusted odds of instant fatal MI: low PA [OR, 0.79 (95% CI, 0.60–1.04)], moderate PA [0.67 (0.51–0.89)], and high PA [0.55 (0.40–0.76)]. Similar results were found for 28-day fatal MI: low PA [0.85 (0.71–1.03)], moderate PA [0.64 (0.51–0.80)], and high PA [0.72 (0.51–1.00)]. A low-to-moderate degree of heterogeneity was detected in the analysis of instant fatal MI (I2 = 47.3%), but not in that of 28-day fatal MI (I2 = 0.0%). Conclusion: A moderate-to-high level of PA was associated with a lower risk of instant and 28-day death in relation to a MI.

• Item Type: Articles
• Additional Information: Funding: The Danish Heart Foundation (18-R124-A8318-22104).
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Ho, Dr Frederick and Celis, Dr Carlos and Gray, Professor Stuart and Pell, Professor Jill
• Authors: Wadt Hansen, K., Peytz, N., Blokstra, A., Bojesen, S. E., Celis-Morales, C., Chrysohoou, C., Clays, E., De Bacquer, D., Galatius, S., Gray, S. R., Ho, F., Kavousi, M., Koolhaas, C. M., Kouvari, M., Løchen, M.-L., Marques-Vida, P., Osler, M., Panagiotakos, D., Pell, J. P., Sulo, G., Tell, G. S., Vassiliou, V., Verschuren, W. M. M., and Prescott, E.
• College/School: College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health; College of Medical Veterinary and Life Sciences > School of Health & Wellbeing > Public Health
• Journal Name: European Journal of Preventive Cardiology
• Publisher: Oxford University Press
• ISSN: 2047-4873
• ISSN (Online): 2047-4881
• Published Online: 10 February 2021
• Copyright Holders: Copyright © 2021 The Authors
• First Published: First published in European Journal of Preventive Cardiology 28(14): 1590-1598
• Publisher Policy: Reproduced in accordance with the publisher copyright policy