Clinical features, diagnosis, and survival analysis of dogs with glioma

Jose-Lopez, R. et al. (2021) Clinical features, diagnosis, and survival analysis of dogs with glioma. Journal of Veterinary Internal Medicine, 35(4), pp. 1902-1917. (doi: 10.1111/jvim.16199) (PMID:34117807) (PMCID:PMC8295679)

Abstract

Background: Gliomas in dogs remain poorly understood. Objectives: To characterize the clinicopathologic findings, diagnostic imaging features and survival of a large sample of dogs with glioma using the Comparative Brain Tumor Consortium diagnostic classification. Animals: Ninety-one dogs with histopathological diagnosis of glioma. Methods: Multicentric retrospective case series. Signalment, clinicopathologic findings, diagnostic imaging characteristics, treatment, and outcome were used. Tumors were reclassified according to the new canine glioma diagnostic scheme. Results: No associations were found between clinicopathologic findings or survival and tumor type or grade. However, definitive treatments provided significantly (P = .03) improved median survival time (84 days; 95% confidence interval [CI], 45-190) compared to palliative treatment (26 days; 95% CI, 11-54). On magnetic resonance imaging (MRI), oligodendrogliomas were associated with smooth margins and T1-weighted hypointensity compared to astrocytomas (odds ratio [OR], 42.5; 95% CI, 2.42-744.97; P = .04; OR, 45.5; 95% CI, 5.78-333.33; P < .001, respectively) and undefined gliomas (OR, 84; 95% CI, 3.43-999.99; P = .02; OR, 32.3; 95% CI, 2.51-500.00; P = .008, respectively) and were more commonly in contact with the ventricles than astrocytomas (OR, 7.47; 95% CI, 1.03-53.95; P = .049). Tumor spread to neighboring brain structures was associated with high-grade glioma (OR, 6.02; 95% CI, 1.06-34.48; P = .04). Conclusions and Clinical Importance: Dogs with gliomas have poor outcomes, but risk factors identified in survival analysis inform prognosis and the newly identified MRI characteristics could refine diagnosis of tumor type and grade.

• Item Type: Articles
• Additional Information: Research Funding: University of Glasgow, Small Animal Hospital Fund Postgraduate Research Grant. Grant Number: 145973-02.
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Gutierrez Quintana, Mr Rodrigo and Jose-Lopez, Mr Roberto
• Authors: Jose-Lopez, R., Gutierrez-Quintana, R., de la Fuente, C., Manzanilla, E. G., Suñol, A., Pi Castro, D., Añor, S., Sánchez-Masian, D., Fernández-Flores, F., Ricci, E., Marioni-Henry, K., Mascort, J., Matiasek, L. A., Matiasek, K., Brennan, P. M., and Pumarola, M.
• College/School: College of Medical Veterinary and Life Sciences > School of Biodiversity, One Health & Veterinary Medicine
• Journal Name: Journal of Veterinary Internal Medicine
• Publisher: Wiley
• ISSN: 0891-6640
• ISSN (Online): 1939-1676
• Published Online: 12 June 2021
• Copyright Holders: Copyright © 2021 The Authors
• First Published: First published in Journal of Veterinary Internal Medicine 35(4): 1902-1917
• Publisher Policy: Reproduced under a Creative Commons License