CancerMine: Knowledge Base Construction for Personalised Cancer Treatment

Lever, J. , Jones, M. and Jones, S. J.M. (2016) CancerMine: Knowledge Base Construction for Personalised Cancer Treatment. In: 2016 Joint International Conference on Biological Ontology and BioCreative - Food, Nutrition, Health and Environment for the 9 Billion (ICBO-BioCreative 2016), Corvallis, OR, USA, 01-04 Aug 2016,

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Knowledge of the relevant genomic aberrations that drive a particular cancer type is necessary to accelerate efficient interpretation of genomic data and enable large-scale endeavours in precision medicine. Currently, this field is limited by the lack of focused and scalable literature curation tools that can reliably capture the required information. Here we present a knowledge-base of genes that have been described in the literature as drivers, oncogenes or tumour suppressors with respect to a specific type of cancer. We have annotated a large body of literature which reports oncogenic aberrations using a custom designed annotation tool. We then applied VERSE, an in-house relation extraction tool, to catalogue driver mutations and illustrate the ability to build a useful resource for clinical interpretation of genomic data for personalised treatment approaches.

Item Type:Conference Proceedings
Glasgow Author(s) Enlighten ID:Lever, Dr Jake
Authors: Lever, J., Jones, M., and Jones, S. J.M.
College/School:College of Science and Engineering > School of Computing Science
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