Franz, L. and Koehnke, J. (2021) Leader peptide exchange to produce hybrid, new-to-nature ribosomal natural products. Chemical Communications, 57, pp. 6372-6375. (doi: 10.1039/D0CC06889F) (PMID:34075907)
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Abstract
Ribosomal natural products contain exquisite post-translational peptide modifications that are installed by a range of pathway-specific enzymes. We present proof of principle for a Sortase A-based approach that enables peptide modifcation by enzymes from unrelated pathways. This allowed the one-pot synthesis of a new-to-nature, hybrid ribosomal natural product.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Koehnke, Professor Jesko |
| Authors: | Franz, L., and Koehnke, J. |
| College/School: | College of Science and Engineering > School of Chemistry |
| Journal Name: | Chemical Communications |
| Publisher: | Royal Society of Chemistry |
| ISSN: | 1359-7345 |
| ISSN (Online): | 1364-548X |
| Published Online: | 24 May 2021 |
| Copyright Holders: | Copyright © 2021 The Royal Society of Chemistry |
| First Published: | First published in Chemical Communications 57: 6372-6375 |
| Publisher Policy: | Reproduced under a Creative Commons License |
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