Magnesium sulphate for treating acute bronchiolitis in children up to two years of age

Chandelia, S., Kumar, D., Chadha, N. and Jaiswal, N. (2020) Magnesium sulphate for treating acute bronchiolitis in children up to two years of age. Cochrane Database of Systematic Reviews, 12, CD012965. (doi: 10.1002/14651858.CD012965.pub2) (PMID:33316083)

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Background: Acute bronchiolitis is a significant burden on children, their families and healthcare facilities. It mostly affects children younger than two years of age. Treatment involves adequate hydration, humidified oxygen supplementation, and nebulisation of medications, such as salbutamol, epinephrine, and hypertonic saline. The effectiveness of magnesium sulphate for acute bronchiolitis is unclear. Objectives: To assess the effects of magnesium sulphate in acute bronchiolitis in children up to two years of age. Search methods: We searched CENTRAL, MEDLINE, Embase, LILACS, CINAHL, and two trials registries to 30 April 2020. We contacted trial authors to identify additional studies. We searched conference proceedings and reference lists of retrieved articles. Unpublished and published studies were eligible for inclusion. Selection criteria: Randomised controlled trials (RCTs) and quasi‐RCTs, comparing magnesium sulphate, alone or with another treatment, with placebo or another treatment, in children up to two years old with acute bronchiolitis. Primary outcomes were time to recovery, mortality, and adverse events. Secondary outcomes were duration of hospital stay, clinical severity score at 0 to 24 hours and 25 to 48 hours after treatment, pulmonary function test, hospital readmission within 30 days, duration of mechanical ventilation, and duration of intensive care unit stay. Data collection and analysis: We used standard methodological procedures expected by Cochrane. We used GRADE methods to assess the certainty of the evidence.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Jaiswal, Dr Nishant
Authors: Chandelia, S., Kumar, D., Chadha, N., and Jaiswal, N.
College/School:College of Medical Veterinary and Life Sciences > School of Health & Wellbeing > Health Economics and Health Technology Assessment
Journal Name:Cochrane Database of Systematic Reviews
ISSN (Online):1469-493X
Copyright Holders:Copyright © 2020 The Cochrane Collaboration
First Published:First published in Cochrane Database of Systematic Reviews 12:CD012965
Publisher Policy:Reproduced in accordance with the publisher copyright policy

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