Trivett, C., Lees, Z. J. and Freeman, D. J. (2021) Adipose tissue function in healthy pregnancy, gestational diabetes mellitus and pre-eclampsia. European Journal of Clinical Nutrition, 75(12), pp. 1745-1756. (doi: 10.1038/s41430-021-00948-9) (PMID:34131300)
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Abstract
Gestational diabetes mellitus (GDM) is a common disorder of pregnancy with short- and long-term consequences for mother and baby. Pre-eclampsia is of major concern to obstetricians due to its sudden onset and increased morbidity and mortality for mother and baby. The incidence of these conditions continues to increase due to widespread maternal obesity. Maternal obesity is a risk factor for GDM and pre-eclampsia, yet our understanding of the role of adipose tissue and adipocyte biology in their aetiology is very limited. In this article, available data on adipose tissue and adipocyte function in healthy and obese pregnancy and how these are altered in GDM and pre-eclampsia are reviewed. Using our understanding of adipose tissue and adipocyte biology in non-pregnant populations, a role for underlying adipocyte dysfunction in the pathological pathways of these conditions is discussed.
Item Type: | Articles |
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Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Lees, Zoe and Freeman, Dr Dilys and Trivett, Cara |
Authors: | Trivett, C., Lees, Z. J., and Freeman, D. J. |
College/School: | College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health |
Journal Name: | European Journal of Clinical Nutrition |
Publisher: | Springer Nature |
ISSN: | 0954-3007 |
ISSN (Online): | 1476-5640 |
Published Online: | 15 June 2021 |
Copyright Holders: | Copyright © 2021 The Authors |
First Published: | First published in European Journal of Clinical Nutrition 75(12): 1745-1756 |
Publisher Policy: | Reproduced under a Creative Commons License |
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