Code for Estimation of Parameters for an Archetypal Model of Cardiomyocyte Membrane Potentials

Aziz, M. H.N. and Simitev, R. D. (2021) Code for Estimation of Parameters for an Archetypal Model of Cardiomyocyte Membrane Potentials. [Artefact]

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Publisher's URL: https://doi.org/10.5281/zenodo.4568662

Abstract

This is a suite of MATLAB/Octave functions for numerical solution of and for estimation of the parameter values of the cardiomyocyte membrane potential model of Biktashev et al. (Bull Math Biol, 70(2), 2008, doi:10.1007/s11538-007-9267-0) - "the archetypal model". In particular, the code can be used determine parameter values for the archetypal model such that its solutions approximate the action potential traces and the action potential duration restitution curves of (a) other electrophysiologically detailed mathematical models of the transmembrane ionic currents of single cardiac myocytes - "target models", as well as (b) traces and curves measured experimentally - "target data". Data and functions for several detailed ionic models from the CellML physiological model repository (cellml.org) are included as examples of usage.

Item Type:Artefact
Additional Information:This work was supported by the UK Engineering and Physical Sciences Research Council [EPSRC grant numbers EP/N014642/1, EP/S030875/1, EP/T017899/1]. M.H.N. Aziz was funded by Ministry of Higher Education Malaysia and University of Malaya under a SLAB scholarship.
Glasgow Author(s) Enlighten ID:Simitev, Dr Radostin
Authors: Aziz, M. H.N., and Simitev, R. D.
College/School:College of Science and Engineering > School of Mathematics and Statistics > Mathematics

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
172141EPSRC Centre for Multiscale soft tissue mechanics with application to heart & cancerRaymond OgdenEngineering and Physical Sciences Research Council (EPSRC)EP/N014642/1M&S - Mathematics
303232EPSRC Centre for Multiscale soft tissue mechanics with MIT and POLIMI (SofTMech-MP)Xiaoyu LuoEngineering and Physical Sciences Research Council (EPSRC)EP/S030875/1M&S - Mathematics
308255The SofTMech Statistical Emulation and Translation HubDirk HusmeierEngineering and Physical Sciences Research Council (EPSRC)EP/T017899/1M&S - Statistics