Al-Ozairi, E. et al. (2021) Risk of mortality among inpatients with COVID-19 and type 2 diabetes: national data from Kuwait. Endocrinology, Diabetes and Metabolism, 4(4), e00287. (doi: 10.1002/edm2.287) (PMID:34505420) (PMCID:PMC8420596)
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Abstract
Introduction To investigate type 2 diabetes as a risk factor for COVID-19 death following hospital admission in Kuwait. Methods A retrospective cohort study using data from a central hospital that cared for all hospitalized COVID-19 patients in Kuwait. We investigated the association between type 2 diabetes, with COVID-19 mortality using multiply imputed logistic regression and calculated the population attributable fraction. Results A total of 5333 patients were admitted with COVID-19, of whom 244 died (4.6%). Diabetes prevalence was 24.8%, but 53.7% of those who died had diabetes. After adjusting for age, sex, ethnicity and other comorbidities, diabetes was associated with death (OR 1.70 [95% CI 1.23, 2.34]) and admission to the intensive care unit more than 3 days after initial admission (OR 1.78 [95% CI 1.17, 2.70]). Assuming causality, the population attributable fraction for type 2 diabetes in COVID-19 death was 19.6% (95% CI 10.8, 35.6). Conclusion Type 2 diabetes is a strong risk factor for COVID-19 death in the Middle East. Given the high prevalence of type 2 diabetes in the Middle East, as well as many Western countries, the public health implications are considerable.
| Item Type: | Articles |
|---|---|
| Keywords: | COVID-19, death, diabetes. |
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Katikireddi, Professor Vittal and Celis, Dr Carlos and Gray, Professor Stuart and Gill, Professor Jason and Brown, Miss Rosemary and Welsh, Professor Paul and Alabdullah, Lulwa and Sattar, Professor Naveed |
| Authors: | Al-Ozairi, E., Brown, R., Hamdan, Y., Alabdullah, L., Voase, N., Al Kandari, J., Alsaeed, D., Al Ozairi, A., Hasan, A., Al-Mulla, F., Katikireddi, S. V., Gray, S. R., Gill, J. M.R., Celis-Morales, C. A., Sattar, N., and Welsh, P. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health College of Medical Veterinary and Life Sciences > School of Health & Wellbeing > MRC/CSO SPHSU |
| Journal Name: | Endocrinology, Diabetes and Metabolism |
| Publisher: | Wiley |
| ISSN: | 2398-9238 |
| ISSN (Online): | 2398-9238 |
| Published Online: | 10 July 2021 |
| Copyright Holders: | Copyright © 2021 The Authors |
| First Published: | First published in Endocrinology, Diabetes and Metabolism 4(4): e00287 |
| Publisher Policy: | Reproduced under a Creative Commons License |
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