The structural biology of patellamide biosynthesis

Koehnke, J. , Bent, A. F., Houssen, W. E., Mann, G., Jaspars, M. and Naismith, J. H. (2014) The structural biology of patellamide biosynthesis. Current Opinion in Structural Biology, 29, pp. 112-121. (doi: 10.1016/ (PMID:25460274) (PMCID:PMC4268494)

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The biosynthetic pathways for patellamide and related natural products have recently been studied by structural biology. These pathways produce molecules that have a complex framework and exhibit a diverse array of activity due to the variability of the amino acids that are found in them. As these molecules are difficult to synthesize chemically, exploitation of their properties has been modest. The patellamide pathway involves amino acid heterocyclization, peptide cleavage, peptide macrocyclization, heterocycle oxidation and epimerization; closely related products are also prenylated. Enzyme activities have been identified for all these transformations except epimerization, which may be spontaneous. This review highlights the recent structural and mechanistic work on amino acid heterocyclization, peptide cleavage and peptide macrocyclization. This work should help in using the enzymes to produce novel analogs of the natural products enabling an exploitation of their properties.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Koehnke, Professor Jesko
Authors: Koehnke, J., Bent, A. F., Houssen, W. E., Mann, G., Jaspars, M., and Naismith, J. H.
College/School:College of Science and Engineering > School of Chemistry
Journal Name:Current Opinion in Structural Biology
ISSN (Online):1879-033X
Copyright Holders:Copyright © 2014 The Authors
First Published:First published in Current Opinion in Structural Biology 29: 112–121
Publisher Policy:Reproduced under a Creative Commons licence

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