Koehnke, J. et al. (2013) An enzymatic route to selenazolines. ChemBioChem, 14(5), pp. 564-567. (doi: 10.1002/cbic.201300037) (PMID:23483642) (PMCID:PMC3625746)
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Abstract
Ringing the changes: Selenazolines have applications in medicinal chemistry, but their synthesis is challenging. We report a new convenient and less toxic route to these heterocycles that starts from commercially available selenocysteine. The new route depends on a heterocyclase enzyme that creates oxazolines and thiazolines from serines/threonines and cysteines.
Item Type: | Articles |
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Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Koehnke, Professor Jesko |
Authors: | Koehnke, J., Morawitz, F., Bent, A. F., Houssen, W. E., Shirran, S. L., Fuszard, M. A., Smellie, I. A., Botting, C. H., Smith, M. C. M., Jaspars, M., and Naismith, J. H. |
College/School: | College of Science and Engineering > School of Chemistry |
Journal Name: | ChemBioChem |
Publisher: | Wiley-VCH Verlag |
ISSN: | 1439-4227 |
ISSN (Online): | 1439-7633 |
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