Spatial heterodyne offset Raman spectroscopy enabling rapid, high sensitivity characterisation of materials’ interfaces

Cui, H. , Glidle, A. and Cooper, J. M. (2021) Spatial heterodyne offset Raman spectroscopy enabling rapid, high sensitivity characterisation of materials’ interfaces. Small, 17(24), 2101114. (doi: 10.1002/smll.202101114) (PMID:34013665)

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Spatially offset Raman spectroscopy is integrated with a fiber-coupled spatial heterodyne spectrometer to collect Raman spectra from deep within opaque or scattering materials. The method, named spatial heterodyne offset Raman spectroscopy generates a wavenumber-dependent spatial phase shift of the optical signal as a “spectral” image on a charge-coupled device detector. The image can be readily processed from the spatial domain using a single, simple, and “on-the-fly” Fourier transform to generate Raman spectra, in the frequency domain. By collecting all of the spatially offset Raman scattered photons that pass through the microscope's collection objective lens, the methodology gives an improvement in the Raman sensitivity by an order of magnitude. The instrumentation is both mechanically robust and “movement-free,” which when coupled with the associated advantages of highly efficient signal collection and ease of data processing, enables rapid interfacial analysis of complex constructs based on established biomaterials models.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Cooper, Professor Jonathan and Cui, Dr Han and Glidle, Dr Andrew
Authors: Cui, H., Glidle, A., and Cooper, J. M.
College/School:College of Science and Engineering > School of Engineering > Biomedical Engineering
Journal Name:Small
ISSN (Online):1613-6829
Published Online:19 May 2021
Copyright Holders:Copyright © 2021 The Authors
First Published:First published in Small 17(24): 2101114
Publisher Policy:Reproduced under a Creative Commons License

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
173192Engineering growth factor microenvironments- a new therapeutic paradigm for regenerative medicineManuel Salmeron-SanchezEngineering and Physical Sciences Research Council (EPSRC)EP/P001114/1ENG - Biomedical Engineering