Spatial heterodyne offset Raman spectroscopy enabling rapid, high sensitivity characterisation of materials’ interfaces

Cui, H. , Glidle, A. and Cooper, J. M. (2021) Spatial heterodyne offset Raman spectroscopy enabling rapid, high sensitivity characterisation of materials’ interfaces. Small, 17(24), 2101114. (doi: 10.1002/smll.202101114) (PMID:34013665)

Abstract

Spatially offset Raman spectroscopy is integrated with a fiber-coupled spatial heterodyne spectrometer to collect Raman spectra from deep within opaque or scattering materials. The method, named spatial heterodyne offset Raman spectroscopy generates a wavenumber-dependent spatial phase shift of the optical signal as a “spectral” image on a charge-coupled device detector. The image can be readily processed from the spatial domain using a single, simple, and “on-the-fly” Fourier transform to generate Raman spectra, in the frequency domain. By collecting all of the spatially offset Raman scattered photons that pass through the microscope's collection objective lens, the methodology gives an improvement in the Raman sensitivity by an order of magnitude. The instrumentation is both mechanically robust and “movement-free,” which when coupled with the associated advantages of highly efficient signal collection and ease of data processing, enables rapid interfacial analysis of complex constructs based on established biomaterials models.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Cooper, Professor Jonathan and Cui, Dr Han and Glidle, Dr Andrew
• Authors: Cui, H., Glidle, A., and Cooper, J. M.
• College/School: College of Science and Engineering > School of Engineering > Biomedical Engineering
• Journal Name: Small
• Publisher: Wiley
• ISSN: 1613-6810
• ISSN (Online): 1613-6829
• Published Online: 19 May 2021
• Copyright Holders: Copyright © 2021 The Authors
• First Published: First published in Small 17(24): 2101114
• Publisher Policy: Reproduced under a Creative Commons License

Project Code	Award No	Project Name	Principal Investigator	Funder's Name	Funder Ref	Lead Dept
173192		Engineering growth factor microenvironments- a new therapeutic paradigm for regenerative medicine	Manuel Salmeron-Sanchez	Engineering and Physical Sciences Research Council (EPSRC)	EP/P001114/1	ENG - Biomedical Engineering