Mactier, H., McCulloch, D. L., Hamilton, R. , Galloway, P., Bradnam, M. S. , Young, D., Lavy, T., Farrell, L. and Weaver, L. T. (2012) Vitamin A supplementation improves retinal function in infants at risk of retinopathy of prematurity. Journal of Pediatrics, 160(6), 954-959.e1. (doi: 10.1016/j.jpeds.2011.12.013) (PMID:22284923)
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Abstract
Objective: Preterm infants show reduced retinal sensitivity at term corrected age compared with newborn term infants. We tested the hypothesis that retinal sensitivity in preterm infants is improved by early, high-dose vitamin A. Study design: We report a double-blind, randomized controlled trial of infants <32 weeks’ gestation and/or <1501 g birth weight. Supplemented infants received additional intramuscular vitamin A 10 000 IU 3 times weekly from day 2 for a minimum of 2 weeks or until establishment of oral feeding. Hepatic stores were assessed by relative dose response (RDR). The primary outcome measure was cone-corrected dark-adapted retinal rod sensitivity measured by electroretinogram at 36 weeks’ postmenstrual age (PMA). Results: Eighty-nine infants (42 supplemented and 47 controls) were recruited. Plasma retinol was higher in supplemented infants at 7 and 28 days (median, 1.0 vs 0.5 μmol/L and 0.7 vs 0.6 μmol/L; P < .001 and .03, respectively). Neither plasma retinol nor RDR differed between groups at 36 weeks’ PMA. Retinal sensitivity was greater in supplemented infants (−0.81 vs −0.61 log cd • s • m−2; P < .03) and was not related to RDR. Conclusions: Early high-dose intramuscular vitamin A supplementation for infants at risk of retinopathy of prematurity improves retinal function at 36 weeks’ PMA.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Weaver, Professor Lawrence and Galloway, Dr Peter and Bradnam, Dr Michael and MacTier, Dr Helen and Hamilton, Dr Ruth and Lavy, Dr Timothy |
| Authors: | Mactier, H., McCulloch, D. L., Hamilton, R., Galloway, P., Bradnam, M. S., Young, D., Lavy, T., Farrell, L., and Weaver, L. T. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing |
| Journal Name: | Journal of Pediatrics |
| Publisher: | Mosby |
| ISSN: | 0022-3476 |
| ISSN (Online): | 1097-6833 |
| Published Online: | 27 January 2012 |
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