Dark-adapted oscillatory potentials in preterm infants with and without retinopathy of prematurity

Mactier, H., Bradnam, M. S. and Hamilton, R. (2013) Dark-adapted oscillatory potentials in preterm infants with and without retinopathy of prematurity. Documenta Ophthalmologica, 127(1), pp. 33-40. (doi: 10.1007/s10633-013-9373-2) (PMID:23334439)

Full text not currently available from Enlighten.


Purpose: To describe the appearance and maturation of dark-adapted oscillatory potentials (OPs) in electroretinograms (ERGs) recorded from preterm infants, and to determine any effect of retinopathy of prematurity (ROP). Methods: Dark-adapted ERGs were recorded in conjunction with screening for ROP and at outpatient follow-up, using a flash luminance of 11.3 scot cd s m−2 (4.06 phot cd s m−2). Eligible infants were born before 31 weeks’ gestation and/or weighed ≤1,250 grams at birth. Results: Presence or absence of OPs was established for 68 ERG recordings from 38 infants at maturities ranging from 30 weeks’ postmenstrual age (PMA) to 28 weeks’ post-term corrected age. 20 infants did not develop ROP, eight developed stage 1, one stage 2 and one stage 3 disease which regressed spontaneously. Eight infants received treatment for threshold ROP. OPs were present in 50 % of infants at 36 weeks’ PMA and in all by 50 weeks’ PMA. The earliest appearance of OPs was at 30+5 weeks’ PMA. Individual OP amplitudes increased and peak time of individual OPs decreased with increasing maturity. For infants with threshold ROP summed OP amplitudes tended to be smaller prior to treatment (6.5 vs 9.9μV, P = 0.09) and were significantly smaller by 50 weeks’ PMA (14 vs 30μV, P = 0.007). OP1 was less likely to be present in infants who developed stage 3 or worse ROP (P = 0.000). Conclusions: Dark-adapted OPs are recordable in some preterm infants from 30 weeks’ PMA. Relative suppression of early OPs is a potential marker for developing ROP.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Bradnam, Dr Michael and MacTier, Dr Helen and Hamilton, Dr Ruth
Authors: Mactier, H., Bradnam, M. S., and Hamilton, R.
College/School:College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing
Journal Name:Documenta Ophthalmologica
ISSN (Online):1573-2622
Published Online:20 January 2013

University Staff: Request a correction | Enlighten Editors: Update this record