Ischemic mitral regurgitation: a multifaceted syndrome with evolving therapies

Vinciguerra, M., Grigioni, F., Romiti, S., Benfari, G., Rose, D., Spadaccio, C., Cimino, S., De Bellis, A. and Greco, E. (2021) Ischemic mitral regurgitation: a multifaceted syndrome with evolving therapies. Biomedicines, 9(5), 447. (doi: 10.3390/biomedicines9050447) (PMID:33919263) (PMCID:PMC8143318)

Abstract

Dysfunction of the left ventricle (LV) with impaired contractility following chronic ischemia or acute myocardial infarction (AMI) is the main cause of ischemic mitral regurgitation (IMR), leading to moderate and moderate-to-severe mitral regurgitation (MR). The site of AMI exerts a specific influence determining different patterns of adverse LV remodeling. In general, inferior-posterior AMI is more frequently associated with regional structural changes than the anterolateral one, which is associated with global adverse LV remodeling, ultimately leading to different phenotypes of IMR. In this narrative review, starting from the aforementioned categorization, we proceed to describe current knowledge regarding surgical approaches in the management of IMR.

• Item Type: Articles
• Keywords: Ischemic mitral regurgitation, symmetric tethering, asymmetric tethering, mitral valve repair, Mitra-Clip.
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Spadaccio, Dr Cristiano

Creator Roles

Spadaccio, C.: Writing – review and editing

• Authors: Vinciguerra, M., Grigioni, F., Romiti, S., Benfari, G., Rose, D., Spadaccio, C., Cimino, S., De Bellis, A., and Greco, E.
• College/School: College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health
• Journal Name: Biomedicines
• Publisher: MDPI
• ISSN: 2227-9059
• ISSN (Online): 2227-9059
• Published Online: 21 April 2021
• Copyright Holders: Copyright © 2021 The Authors
• First Published: First published in Biomedicines 9(5): 447
• Publisher Policy: Reproduced under a Creative Commons License