La Thangue, N. (2007) Control of the p53 response. Toxicology, 240, p. 134. (doi: 10.1016/j.tox.2007.06.011)
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Abstract
A hallmark of tumour cells is evident in the control of the G1 to S phase transition. In normal cells the transition is tightly regulated whereas tumour cells progress liberally into S phase in an unrestrained fashion. p53 is a DNA damage responsive transcription factor that activates genes involved with apoptosis and cell cycle arrest. Most tumour cells harbour mutations that alter p53 activity, causing insensitivity to checkpoint control. The p53 response is influenced by transcriptional co-factors that assemble with p53 during the DNA damage response. Our studies have unearthed new levels of control on the p53 response imparted by co-factors that regulate the transcriptional activity of p53.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | UNSPECIFIED |
| Authors: | La Thangue, N. |
| College/School: | College of Medical Veterinary and Life Sciences |
| Journal Name: | Toxicology |
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