Milton, A., Luoto, K., Ingram, L., Munro, S., Logan, N., Graham, A.L., Brummelhamp, T.R., Hijmans, E.M., Bernards, R. and La Thangue, N.B. (2006) A functionally distinct member of the DP family of E2F subunits. Oncogene, 25(22), pp. 3212-3218. (doi: 10.1038/sjonc.1209343) (PMID:16418725)
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Abstract
E2F transcription factors regulate genes involved in cell-cycle progression. In mammalian cells, physiological E2F exists as an E2F/DP heterodimer. Currently, eight E2F and two DP subunits have been characterized. We report here the characterization of a new member of the DP family, DP-4. While DP-4 exhibits certain similarities with members of the DP family, it also possesses a number of significant differences. Thus, DP-4 forms a heterodimer with E2F subunits, binds to the E2F site and associates with pocket proteins including pRb. In contrast to DP-1, however, DP-4/E2F-1 complexes exhibit reduced DNA binding activity. Furthermore, DP-4 interferes with E2F-1-dependent transcription and delays cell-cycle progression. These results highlight an emerging complexity in the DP family of E2F subunits, and suggest that DP-4 may endow E2F heterodimers with distinct transcription properties.
Item Type: | Articles |
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Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | McKenna, Mrs Anne |
Authors: | Milton, A., Luoto, K., Ingram, L., Munro, S., Logan, N., Graham, A.L., Brummelhamp, T.R., Hijmans, E.M., Bernards, R., and La Thangue, N.B. |
College/School: | College of Medical Veterinary and Life Sciences > School of Biodiversity, One Health & Veterinary Medicine |
Journal Name: | Oncogene |
Publisher: | Nature Publishing Group |
ISSN: | 0950-9232 |
ISSN (Online): | 1476-5594 |
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