Cell adhesion receptors, tyrosine kinases and actin modulators: a complex three-way circuitry

Brunton, V.G., MacPherson, I.R.J. and Frame, M.C. (2004) Cell adhesion receptors, tyrosine kinases and actin modulators: a complex three-way circuitry. Biochimica et Biophysica Acta: Molecular Cell Research, 1692(02-Mar), pp. 121-144. (doi: 10.1016/j.bbamcr.2004.04.010)

Abstract

The interaction of cells with surrounding matrix and neighbouring cells governs many aspects of cell behaviour. Aside from transmitting signals from the external environment, adhesion receptors also receive signals from the cell interior. Here we review the interrelationship between adhesion receptors, tyrosine kinases (both growth factor receptor and non-receptor) and modulators of the actin cytoskeletal network. Deregulation of many aspects of these signalling pathways in cancer highlights the need for a better understanding of the complexities involved.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: MacPherson, Professor Iain
• Authors: Brunton, V.G., MacPherson, I.R.J., and Frame, M.C.
• College/School: College of Medical Veterinary and Life Sciences > School of Cancer Sciences
• Journal Name: Biochimica et Biophysica Acta: Molecular Cell Research
• ISSN: 0167-4889